Literature DB >> 6893362

Fatal myeloencephalopathy caused by intrathecal vincristine.

H Slyter, B Liwnicz, M K Herrick, R Mason.   

Abstract

Vincristine sulfate was inadvertently given intrathecally to a woman with lymphoma, producing ascending sensory and motor dysfunction followed by encephalopathy and death. Pathologically, neurons were swollen by aggregates of neurofilaments similar to the neurofilaments described in experimental models of vincristine neurotoxicity.

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Year:  1980        PMID: 6893362     DOI: 10.1212/wnl.30.8.867

Source DB:  PubMed          Journal:  Neurology        ISSN: 0028-3878            Impact factor:   9.910


  7 in total

1.  Accidental iatrogenic intoxications by cytotoxic drugs: error analysis and practical preventive strategies.

Authors:  B Zernikow; E Michel; G Fleischhack; U Bode
Journal:  Drug Saf       Date:  1999-07       Impact factor: 5.606

Review 2.  Intrathecal vincristine: a fatal chemotherapeutic error with devastating central nervous system effects.

Authors:  P G Bain; P L Lantos; V Djurovic; I West
Journal:  J Neurol       Date:  1991-07       Impact factor: 4.849

3.  Intracytoplasmic eosinophilic inclusions in the neurons of the central nervous system.

Authors:  C E Peña; A Katoh
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

Review 4.  Vincristine neurotoxicity. Pathophysiology and management.

Authors:  S S Legha
Journal:  Med Toxicol       Date:  1986 Nov-Dec

5.  Syndrome of inappropriate secretion of antidiuretic hormone caused by vincristine therapy: a case report of the neuropathology.

Authors:  K Tomiwa; H Mikawa; F Hazama; K Yazawa; R Hosoya; T Ohya; K Nishimura
Journal:  J Neurol       Date:  1983       Impact factor: 4.849

6.  Accidental intrathecal vincristine administration. Report of a case.

Authors:  J Manelis; E Freudlich; E Ezekiel; J Doron
Journal:  J Neurol       Date:  1982       Impact factor: 4.849

7.  Neurotoxicology of vincristine in the cat. Morphological study.

Authors:  E S Cho; H E Lowndes; B D Goldstein
Journal:  Arch Toxicol       Date:  1983-02       Impact factor: 5.153

  7 in total

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