Literature DB >> 689258

[Somatotropin, antidot against phalloidin (author's transl)].

H Schimassek, D Jeckel, W G Forssmann, H Undi.   

Abstract

1. Somatotropin protects rats against a lethal dose of phalloidin (1.3 mg/kg). 2. Scanning electron microscopy has shown that 2 hours after phalloidin injection the liver from a somatotropin-pretreated rat is not significantly different to that from an untreated rat. Phalloidin alone caused complete destruction of the structure of the liver lobules. 3. Somatotropin does not prevent phalloidin uptake by the liver but slows down elimination. 4. The findings are discussed with respect to their therapeutic possibilities as somatropin protects rats against death also after phalloidin poisoning.

Entities:  

Mesh:

Substances:

Year:  1978        PMID: 689258

Source DB:  PubMed          Journal:  Cytobiologie        ISSN: 0070-2463


  1 in total

1.  Uptake of 3H-demethylphalloin by isolated hepatocytes in the presence of various concentrations of phalloin or phalloidin.

Authors:  M Frimmer; E Petzinger; K Ziegler; L B Veil
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-02       Impact factor: 3.000

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.