Literature DB >> 6891217

Non-steroidal anti-inflammatories--XII. Mode of action of anti-inflammatory methane sulfonanilides.

C Rufer, E Schillinger, I Böttcher, W Repenthin, C Herrmann.   

Abstract

The influence of anti-inflammatory methane sulfonanilides on the arachidonic acid metabolism in ram seminal vesicle homogenate depends on the pK3 of the individual substance: more acidic compounds suppress, less acidic compounds stimulate PG synthesis and enhance the PGH2/PGG2 ratio. As oxygen radicals are liberated during the conversion of PGG2 to PGH2 it is suggested that the less acidic methane sulfonanilides are scavengers of the (pro-inflammatory) oxygen radicals.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 6891217     DOI： 10.1016/0006-2952(82)90580-9

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  18 in total

1.  Inhibition of neutrophil oxidative metabolism by nimesulide.

Authors:  F Capsoni; E Venegoni; F Minonzio; A M Ongari; V Maresca; C Zanussi
Journal:  Agents Actions       Date:  1987-06

2.  A multicentre double-blind investigation comparing nimesulide and naproxen in the treatment of minor sport injuries.

Authors:  A Calligaris; I Scaricabarozzi; L Vecchiet
Journal:  Drugs       Date:  1993       Impact factor: 9.546

3.  Assessment of the efficacy and safety of nimesulide vs naproxen in paediatric patients with respiratory tract infections. A comparative single-blind study.

Authors:  L E Salmòn Rodriguez; H A Arista Viveros; M E Lujan; R M Maciel; C L Trujillo; E Lopez
Journal:  Drugs       Date:  1993       Impact factor: 9.546

4.  A controlled clinical study of the efficacy and tolerability of nimesulide vs naproxen in maxillo-facial surgery.

Authors:  G Ferrari Parabita; U Zanetti; F Scalvini; D Rossi; I Scaricabarozzi
Journal:  Drugs       Date:  1993       Impact factor: 9.546

5.  Anti-inflammatory activity of topical nimesulide gel in various experimental models.

Authors:  S K Gupta; J Prakash; L Awor; S Joshi; T Velpandian; S Sengupta
Journal:  Inflamm Res       Date:  1996-12       Impact factor: 4.575

6.  A comparison of nimesulide and placebo in the treatment of minor traumatic soft tissue lesions in children.

Authors:  M Giovannini; G V Zuccotti; I Scaricabarozzi; V Locatelli; E Riva
Journal:  Drugs       Date:  1993       Impact factor: 9.546

7.  Double-blind evaluation of nimesulide vs lysine-aspirin in the treatment of paediatric acute respiratory tract infections.

Authors:  I Barberi; A Macchia; N Spata; I Scaricabarozzi; M L Nava
Journal:  Drugs       Date:  1993       Impact factor: 9.546

8.  Efficacy of nimesulide in the prevention of inflammatory complications after laser treatment of ocular diseases.

Authors:  C Marconcini; E Sbrana; I Scaricabarozzi
Journal:  Drugs       Date:  1993       Impact factor: 9.546

9.  Double-blind study of nimesulide in divers with inflammatory disorders of the ear, nose and throat.

Authors:  G Banchini; I Scaricabarozzi; U Montecorboli; A Ceccarelli; F Chiesa; L Ditri; G Mazzer; R Moroni; M Viola; F Roggia
Journal:  Drugs       Date:  1993       Impact factor: 9.546

10.  Controlled clinical studies of nimesulide in the treatment of urogenital inflammation.

Authors:  T Lotti; V Mirone; C Imbimbo; F Corrado; G Corrado; F Garofalo; I Scaricabarozzi
Journal:  Drugs       Date:  1993       Impact factor: 9.546
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.