Studies of the binding interactions of cis-diamminedichloroplatinum(II) with amines and nucleosides by nitrogen-15 nuclear magnetic resonance.

The 15N chemical shifts and couplings have been measured for several platinum(II)-amine complexes. The 15N chemical shift changes found on coordination of azine-type nitrogens to platinum appear to be related to those that occur on protonation of the same nitrogens. Both the 15N chemical shifts and the one-bond 15N-195Pt coupling constants depend on the nature of the cis and trans ligands. cis-[Pt(NH3)2Cl2] ("cis-platinum") forms a complex with cytidine through N3. Guanosine becomes bound to platinum of cis-[Pt(NH3)2Cl2] at N7 and at least one other nitrogen. Adenosine appears to bind cis-[Pt(NH3)2Cl2] to at least some degree through N1, N3, N7, and the 6' -NH2.