Literature DB >> 6890002

"Two route chemotherapy" using cis-diamminedichloro-platinum(II) and its antidote, sodium thiosulfate, for peritoneally disseminated cancer in rats.

S Taniguchi, T Baba.   

Abstract

The effects of "two route chemotherapy" using cis-diamminedichloroplatinum-(II) (DDP) and its antidote sodium thiosulfate (STS), given ip and sc, respectively, were assessed in the case of peritoneally disseminated cancer in rats. Administration of STS sc to mice 1 min before DDP ip was found to be the most effective in protecting the animals against the lethal toxicity of DDP. The LD50 values of DDP ip with and without STS were about 55 mg/kg and 14 mg/kg, respectively. This "two route chemotherapy" using DDP and STS was significantly superior in therapeutic efficacy to single treatment with DDP.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 6890002

Source DB:  PubMed          Journal:  Gan        ISSN： 0016-450X


  13 in total

1.  Protection of antiproliferative effect of cis-diamminedichloroplatinum (II) by sodium thiosulfate.

Authors:  R Abe; T Akiyoshi; H Tsuji; T Baba
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

2.  "Two-route chemotherapy" using cis-diamminedichloroplatinum(II) and its antidote, sodium thiosulfate, combined with angiotensin II is effective against peritoneally disseminated cancer in rats.

Authors:  H Kobayashi; K Hasuda; K Aoki; T Kuroiwa; S Taniguchi; T Baba
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

3.  Increased therapeutic effect on metastatic liver tumors in rats of two-route chemotherapy using cis-diamminedichloroplatinum (II) and its antidote, sodium thiosulfate, with temporary clamping of the abdominal aorta.

Authors:  K Hasuda; H Kobayashi; K Aoki; S Taniguchi; T Baba
Journal:  Cancer Chemother Pharmacol       Date:  1990       Impact factor: 3.333

4.  Inactivation of cis-diamminedichloroplatinum (II) in blood and protection of its toxicity by sodium thiosulfate in rabbits.

Authors:  Y Iwamoto; T Kawano; M Ishizawa; K Aoki; T Kuroiwa; T Baba
Journal:  Cancer Chemother Pharmacol       Date:  1985       Impact factor: 3.333

5.  Sodium thiosulfate inhibits cis-diamminedichloroplatinum (II) activity.

Authors:  J Uozumi; M Ishizawa; Y Iwamoto; T Baba
Journal:  Cancer Chemother Pharmacol       Date:  1984       Impact factor: 3.333

6.  Upper hemibody infusion of cis-diamminedichloroplatinum (II) followed by systemic antidote, sodium thiosulfate, for lung metastasis in rats.

Authors:  Y Iwamoto; K Aoki; T Kawano; T Baba
Journal:  Clin Exp Metastasis       Date:  1984 Jul-Sep       Impact factor: 5.150

7.  Experimental and clinical studies on the intraperitoneal administration of cis-diamminedichloroplatinum (II) for peritoneal carcinomatosis caused by gastric cancers.

Authors:  T Furukawa; K Kumai; T Kubota; S Hirahata; H Shimizu; H Matsui; T Takahara; K Aizawa; S Shibata; A Shimada
Journal:  Surg Today       Date:  1993       Impact factor: 2.549

Review 8.  Some aspects of size-dependent differential drug response in primary and metastatic tumors.

Authors:  I Abe; M Suzuki; K Hori; S Saito; H Sato
Journal:  Cancer Metastasis Rev       Date:  1985       Impact factor: 9.264

9.  Inhibition of cis-diamminedichloroplatinum (II)--induced renal toxicity in the rat.

Authors:  M M Jones; M A Basinger; W M Mitchell; C A Bradley
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

10.  "Two route infusion chemotherapy" using cis-Diamminedichloroplatinum (II) and its antidote, sodium thiosulfate, for metastatic liver tumors in rats.

Authors:  J Uozumi; K Sagiyama; S Taniguchi; Y Iwamoto; K Aoki; T Baba
Journal:  Jpn J Surg       Date:  1982
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.