Literature DB >> 6888653

Calcium-dependent [3H]acetylcholine release and muscarinic autoreceptors in rat cortical synaptosomes during development.

M Marchi, A Caviglia, P Paudice, M Raiteri.   

Abstract

A number of presynaptic cholinergic parameters (high affinity [3H]choline uptake, [3H]acetylcholine synthesis, [3H]acetylcholine release, and autoinhibition of [3H]acetylcholine release mediated by muscarinic autoreceptors) were comparatively analyzed in rat brain cortex synaptosomes during postnatal development. These various functions showed a differential time course during development. At 10 days of age the release of [3H]acetylcholine evoked by 15 mM KCl from superfused synaptosomes was Ca2+-dependent but insensitive to the inhibitory action of extrasynaptosomal acetylcholine. The muscarinic autoreceptors regulating acetylcholine release were clearly detectable only at 14 days, indicating that their appearance may represent a criterion of synaptic maturation more valuable than the onset of a Ca2+-dependent release.

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Year:  1983        PMID： 6888653     DOI： 10.1007/bf00964701

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  16 in total

1.  The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

Authors:  E G GRAY; V P WHITTAKER
Journal:  J Anat       Date:  1962-01       Impact factor: 2.610

Review 2.  Biochemical aspects of neurotransmission in the developing brain.

Authors:  J T Coyle
Journal:  Int Rev Neurobiol       Date:  1977       Impact factor: 3.230

3.  Depression of acetylcholine release from cerebral cortical slices by cholinesterase inhibition and by oxotremorine.

Authors:  J C Szerb; G T Somogyi
Journal:  Nat New Biol       Date:  1973-01-24

Review 4.  Presynaptic receptors.

Authors:  K Starke
Journal:  Annu Rev Pharmacol Toxicol       Date:  1981       Impact factor: 13.820

5.  A simple apparatus for studying the release of neurotransmitters from synaptosomes.

Authors:  M Raiteri; F Angelini; G Levi
Journal:  Eur J Pharmacol       Date:  1974-03       Impact factor: 4.432

6.  Ontogeny of muscarinic receptors in rat brain.

Authors:  M J Kuhar; N J Birdsall; A S Burgen; E C Hulme
Journal:  Brain Res       Date:  1980-02-24       Impact factor: 3.252

7.  Development and aging of cholinergic synapses. VI. Mechanisms of acetylcholine biosynthesis in the chick iris.

Authors:  M Marchi; D W Hoffman; E Giacobini; R Volle
Journal:  Dev Neurosci       Date:  1981       Impact factor: 2.984

8.  Muscarinic receptors on dopamine terminals in the cat caudate nucleus: neuromodulation of [3H]dopamine release in vitro by endogenous acetylcholine.

Authors:  J Lehmann; S Z Langer
Journal:  Brain Res       Date:  1982-09-23       Impact factor: 3.252

9.  Ontogenetic development of high potassium- and acetylcholine-induced release of dopamine from striatal slices of the rat.

Authors:  Y Nomura; I Yotsumoto; T Segawa
Journal:  Brain Res       Date:  1981-04       Impact factor: 3.252

10.  Postnatal development of presynaptic alpha-adrenoceptors in rat cerebral cortex: studies with brain slices and synaptosomes.

Authors:  J Wemer; A H Mulder
Journal:  Brain Res       Date:  1981-03-16       Impact factor: 3.252
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  1 in total

1.  The activation of phosphatidylinositol turnover is not directly involved in the modulation of neurotransmitter release mediated by presynaptic muscarinic receptors.

Authors:  M Marchi; G Fontana; P Paudice; M Raiteri
Journal:  Neurochem Res       Date:  1988-09       Impact factor: 3.996
  1 in total

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