Literature DB >> 688723

Effects of folic acid on phenytoin kinetics in healthy subjects.

M Furlanut, P Benetello, A Avogaro, R Dainese.   

Abstract

Phenytoin (DPH) disposition was studied in normal subjects before and after treatment with folic acid for 14 days. Our results suggest that folic acid lowers (DPH) serum levels without significantly modifying its bound fraction and increases the rate of DPH and meta-hydroxydiphenylhydantoin excretion in urine.

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Year:  1978        PMID： 688723     DOI： 10.1002/cpt1978243294

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  8 in total

Review 1.  Pharmacokinetic drug interactions with phenytoin (Part II).

Authors:  R L Nation; A M Evans; R W Milne
Journal:  Clin Pharmacokinet       Date:  1990-02       Impact factor: 6.447

Review 2.  The influence of nutrition on the systemic availability of drugs. Part II: Drug metabolism and renal excretion.

Authors:  I Walter-Sack
Journal:  Klin Wochenschr       Date:  1987-11-02

Review 3.  Drug interactions with phenytoin.

Authors:  E Perucca; A Richens
Journal:  Drugs       Date:  1981-02       Impact factor: 9.546

4.  Antiepileptic drugs: metabolism in pregnancy.

Authors:  M Dam; J Christiansen; O Munck; K I Mygind
Journal:  Clin Pharmacokinet       Date:  1979 Jan-Feb       Impact factor: 6.447

Review 5.  Drugs and folate metabolism.

Authors:  D G Lambie; R H Johnson
Journal:  Drugs       Date:  1985-08       Impact factor: 9.546

Review 6.  Pharmacokinetic interactions with antiepileptic drugs.

Authors:  E Perucca
Journal:  Clin Pharmacokinet       Date:  1982 Jan-Feb       Impact factor: 6.447

Review 7.  Influence of diet and nutritional status on drug metabolism.

Authors:  I Walter-Sack; U Klotz
Journal:  Clin Pharmacokinet       Date:  1996-07       Impact factor: 6.447

8.  Phenytoin, folic acid and gingival enlargement: Breaking myths.

Authors:  Abhishek Singh Nayyar; Mubeen Khan; K R Vijayalakshmi; B Suman; G T Subhas; B Nataraju; M Anitha
Journal:  Contemp Clin Dent       Date:  2014-01
  8 in total

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