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Literature DB >> 6887024

The influence of pH on the healing-over of mammalian cardiac muscle.

Abstract

The process of healing-over was followed in trabeculae from the right ventricle of guinea-pigs and in Purkinje fibres from dogs by measuring resting potential and input resistance close to a site of damage. In Ca2+-free bathing solution at pH 6.5 no signs of healing-over were found; at pH 5.5 healing-over was incomplete; at pH 5.0 and 4.0 healing-over occurred promptly. It is concluded that transformation of low-resistance nexus membranes into high-resistance membranes separating the intracellular from the extracellular compartment normally is due to Ca2+, while protons can bring about the same effect under extreme conditions.

Entities: Chemical Species

Mesh：

Substances：
Calcium

Year: 1983 PMID： 6887024 PMCID： PMC1199162 DOI： 10.1113/jphysiol.1983.sp014717

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

13 in total

1. The electrical constants of Purkinje fibres.

Authors: S WEIDMANN
Journal: J Physiol Date: 1952-11 Impact factor: 5.182

2. An analysis of the end-plate potential recorded with an intracellular electrode.

Authors: P FATT; B KATZ
Journal: J Physiol Date: 1951-11-28 Impact factor: 5.182

3. The normal membrane potential of frog sartorius fibers.

Authors: G LING; R W GERARD
Journal: J Cell Comp Physiol Date: 1949-12

4. Carbon dioxide reversibly abolishes ionic communication between cells of early amphibian embryo.

Authors: L Turin; A Warner
Journal: Nature Date: 1977-11-03 Impact factor: 49.962

5. Intracellular pH, intracellular free Ca, and junctional cell-cell coupling.

Authors: B Rose; R Rick
Journal: J Membr Biol Date: 1978-12-29 Impact factor: 1.843

6. A study on the healing-over of myocardial cells of toads.

Authors: W C de Mello; G E Motta; M Chapeau
Journal: Circ Res Date: 1969-03 Impact factor: 17.367

7. Gap junctional conductance: comparison of sensitivities to H and Ca ions.

Authors: D C Spray; J H Stern; A L Harris; M V Bennett
Journal: Proc Natl Acad Sci U S A Date: 1982-01 Impact factor: 11.205

8. Influence of intracellular injection of H+ on the electrical coupling in cardiac Purkinje fibres.

Authors: W C De Mello
Journal: Cell Biol Int Rep Date: 1980-01

9. Interactions between the regulation of the intracellular pH and sodium activity of sheep cardiac Purkinje fibres.

Authors: J W Deitmer; D Ellis
Journal: J Physiol Date: 1980-07 Impact factor: 5.182

10. Intracellular pH in early Xenopus embryos: its effect on current flow between blastomeres.

Authors: L Turin; A E Warner
Journal: J Physiol Date: 1980-03 Impact factor: 5.182

12 in total

1. Increase in gap junction resistance with acidification in crayfish septate axons is closely related to changes in intracellular calcium but not hydrogen ion concentration.

Authors: C Peracchia
Journal: J Membr Biol Date: 1990-01 Impact factor: 1.843

6. Evidence for the presence of electrotonic depression of pacemakers in the rabbit atrioventricular node. The effects of uncoupling from the surrounding myocardium.

Authors: C J Kirchhof; F I Bonke; M A Allessie
Journal: Basic Res Cardiol Date: 1988 Mar-Apr Impact factor: 17.165

The influence of pH on the healing-over of mammalian cardiac muscle.

1. The electrical constants of Purkinje fibres.

2. An analysis of the end-plate potential recorded with an intracellular electrode.

3. The normal membrane potential of frog sartorius fibers.

4. Carbon dioxide reversibly abolishes ionic communication between cells of early amphibian embryo.

5. Intracellular pH, intracellular free Ca, and junctional cell-cell coupling.

6. A study on the healing-over of myocardial cells of toads.

7. Gap junctional conductance: comparison of sensitivities to H and Ca ions.

8. Influence of intracellular injection of H+ on the electrical coupling in cardiac Purkinje fibres.

9. Interactions between the regulation of the intracellular pH and sodium activity of sheep cardiac Purkinje fibres.

10. Intracellular pH in early Xenopus embryos: its effect on current flow between blastomeres.

1. Increase in gap junction resistance with acidification in crayfish septate axons is closely related to changes in intracellular calcium but not hydrogen ion concentration.

Review 2. Regulation of gap junction coupling in the developing neocortex.

Review 3. Cell-to-cell coupling assayed by means of electrical measurements.

4. Dependence of junctional conductance on proton, calcium and magnesium ions in cardiac paired cells of guinea-pig.

5. The influence of the atrial myocardium on impulse formation in the rabbit sinus node.

6. Evidence for the presence of electrotonic depression of pacemakers in the rabbit atrioventricular node. The effects of uncoupling from the surrounding myocardium.

7. Influence of halothane on electrical coupling in cell pairs isolated from guinea-pig ventricle.

Review 8. Impulse propagation from the SA-node to the ventricles.

9. Gap junction gating sensitivity to physiological internal calcium regardless of pH in Novikoff hepatoma cells.

10. Pace-maker current changes during intracellular pH transients in sheep cardiac Purkinje fibres.