Testing for hepatitis B virus in patients with chronic urticaria and angioedema.

Serologic markers of hepatitis B virus (HBV) infection were sought in serum from 85 (75%) of 114 consecutive patients with chronic urticaria and angioedema (CUA). Markers of HBV infection were detected in 15 (17.6%) patients. Of these 13 (15.3%) were found to have anti-hepatitis B surface antibody (anti-HBs) and 2 (2.4%) had hepatitis B surface antigen (HBsAg). The frequency of current and previous HBV infection is thus several times greater than that reported in the general population. No patient was found to have anti-HBs and HBsAg detectable in the same sample of blood. A diagnosis of chronic persistent hepatitis was established in the two patients with HBsAg in their circulation. The possibility that CUA was causally related to HBV infection in these two cases, as well as those with anti-HBs, was considered and it was suggested that further exploration of the relationship between CUA and HBV infection is warranted.