Literature DB >> 6885634

Antibiotic A 19009. Structural investigation and synthesis.

J L van der Baan, J W Barnick, F Bickelhaupt.   

Abstract

The structure of fermentation product A 19009 was reinvestigated by 13C and 1H NMR spectroscopy and established by independent synthesis to be N2-L-alanyl-N3-fumaramoyl-L-2,3-diaminopropanoic acid (2), i.e. a structure isomeric with the originally proposed structure 1. In contrast to 1 which also was synthesized, 2 has a very low activity against Trichomonas vaginalis.

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Year:  1983        PMID: 6885634     DOI: 10.7164/antibiotics.36.784

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  3 in total

1.  The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics.

Authors:  Marie A Hollenhorst; Jon Clardy; Christopher T Walsh
Journal:  Biochemistry       Date:  2009-11-03       Impact factor: 3.162

2.  Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics - synthesis and properties.

Authors:  Joanna Stefaniak; Michał G Nowak; Marek Wojciechowski; Sławomir Milewski; Andrzej S Skwarecki
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

3.  Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases.

Authors:  Jessica Dawlaty; Xiaorong Zhang; Michael A Fischbach; Jon Clardy
Journal:  J Nat Prod       Date:  2010-03-26       Impact factor: 4.050

  3 in total

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