Literature DB >> 6884519

Calcium-induced Ca2+ release from sarcoplasmic reticulum of pigs susceptible to malignant hyperthermia. The effects of halothane and dantrolene.

S T Ohnishi, S Taylor, G A Gronert.   

Abstract

Calcium-induced calcium release and halothane-induced calcium release from pig sarcoplasmic reticulum (SR) were studied. The SR prepared from pigs susceptible to malignant hyperthermia (MH) was shown to release calcium at a much lower level of calcium content than in normal pig SR. The concentration above which halothane can release calcium is 40 microM for both MH-SR and normal SR, although the latter required a high calcium content to demonstrate the calcium release. Dantrolene was shown to inhibit the halothane-induced calcium release. Results suggest that SR plays an important role in pathogenesis of MH.

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Year:  1983        PMID： 6884519     DOI： 10.1016/0014-5793(83)80739-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  23 in total

1.  Characterization of high-affinity ryanodine-binding sites of rat liver endoplasmic reticulum. Differences between liver and skeletal muscle.

Authors:  V Shoshan-Barmatz; T A Pressley; S Higham; N Kraus-Friedmann
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

2.  Diagnosis of susceptibility to malignant hyperthermia with flanking DNA markers.

Authors:  S J Healy; J J Heffron; M Lehane; D G Bradley; K Johnson; T V McCarthy
Journal:  BMJ       Date:  1991-11-16

3.  Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.

Authors:  Huihui Kong; Ruiwu Wang; Wenqian Chen; Lin Zhang; Keyun Chen; Yakhin Shimoni; Henry J Duff; S R Wayne Chen
Journal:  Biophys J       Date:  2007-01-26       Impact factor: 4.033

4.  Abnormal ryanodine receptor channels in malignant hyperthermia.

Authors:  M Fill; R Coronado; J R Mickelson; J Vilven; J J Ma; B A Jacobson; C F Louis
Journal:  Biophys J       Date:  1990-03       Impact factor: 4.033

5.  Spectroscopic determination of sarcoplasmic reticulum Ca2+ uptake and Ca2+ release.

Authors:  J S Gilchrist; C Palahniuk; R Bose
Journal:  Mol Cell Biochem       Date:  1997-07       Impact factor: 3.396

Review 6.  Etiopathogenetic defect of malignant hyperthermia: hypersensitive calcium-release channel of skeletal muscle sarcoplasmic reticulum.

Authors:  P J O'Brien
Journal:  Vet Res Commun       Date:  1987       Impact factor: 2.459

Review 7.  Ryanodine receptor patents.

Authors:  Alexander Kushnir; Andrew R Marks
Journal:  Recent Pat Biotechnol       Date:  2012-12

Review 8.  Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity.

Authors:  A Ward; M O Chaffman; E M Sorkin
Journal:  Drugs       Date:  1986-08       Impact factor: 9.546

9.  Abnormal human sarcoplasmic reticulum Ca2+ release channels in malignant hyperthermic skeletal muscle.

Authors:  M Fill; E Stefani; T E Nelson
Journal:  Biophys J       Date:  1991-05       Impact factor: 4.033

10.  Porcine malignant hyperthermia susceptibility: hypersensitive calcium-release mechanism of skeletal muscle sarcoplasmic reticulum.

Authors:  P J O'Brien
Journal:  Can J Vet Res       Date:  1986-07       Impact factor: 1.310
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