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Literature DB >> 6883624

Plasma levels of 7-hydroxymethotrexate after high-dose methotrexate treatment.

G Milano, A Thyss, N Renee, M Schneider, M Namer, J L Boublil, C M Lalanne.

Abstract

Thirteen patients with cancer being treated with high-dose methotrexate (MTX) chemotherapy (350-5,000 mg/6 h IV were entered in this study. Plasma levels of MTX and 7-OHMTX, its main circulating metabolite, were measured by an HPLC technique. 7-OHMTX appears rapidly in the blood, reaching a maximum 6-12 h after the beginning of treatment. The elimination of 7-OHMTX is slower than that of MTX, but the elimination half-lives (24-48 h) are not significantly different: 25.2 h for 7-OHMTX versus 20.3 h for MTX. In all cases, 24 h after starting infusion plasma levels of 7-OHMTX exceeded those of MTX. There was a positive and significant correlation between the dose administered and peak plasma 7-OHMTX. Finally, 7-OHMTX formation was shown to be relatively stable throughout the treatment.

Entities: Chemical Species

Mesh：

Substances：

Year: 1983 PMID： 6883624 DOI： 10.1007/bf00257412

Source DB: PubMed Journal: Cancer Chemother Pharmacol ISSN： 0344-5704 Impact factor: 3.333

12 in total

4. Renal excretion and pharmacokinetics of methotrexate and 7-hydroxy-methotrexate following a 24-h high dose infusion of methotrexate in children.

Authors: B Winograd; R J Lippens; M J Oosterbaan; M J Dirks; T B Vree; E van der Kleijn
Journal: Eur J Clin Pharmacol Date: 1986 Impact factor: 2.953

4 in total

Plasma levels of 7-hydroxymethotrexate after high-dose methotrexate treatment.

Review 1. Clinical pharmacokinetics of methotrexate.

2. Analysis of methotrexate in human plasma by high-pressure liquid chromatography with fluorescence detection.

3. Clinical pharmacology of methotrexate.

4. Synthesis of methotrexate polyglutamates in cultured human cells.

5. Synthesis of methotrexate polyglutamates by bone marrow cells from patients with leukemia and lymphoma.

6. Metabolism of methotrexate in man after high and conventional doses.

7. Renal clearance of methotrexate in man during high-dose oral and intravenous infusion therapy.

8. Methotrexate polyglutamate synthesis by cultured human breast cancer cells.

9. 7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate.

10. The role of 7-hydroxymethotrexate during methotrexate anti-cancer therapy.

1. 7-Hydroxymethotrexate concentrations in serum and cerebrospinal fluid of children with acute lymphoblastic leukemia.

Review 2. Pharmacokinetics of anticancer drugs in children.

3. Kinetics of 7-hydroxy-methotrexate after high-dose methotrexate therapy.

4. Renal excretion and pharmacokinetics of methotrexate and 7-hydroxy-methotrexate following a 24-h high dose infusion of methotrexate in children.