| Literature DB >> 6882616 |
L A Milne, N E Williams, T N Calvey, G R Murray, K Chan.
Abstract
The effect of urine pH on the plasma concentration and elimination of phenoperidine and its main metabolites was studied in six volunteers. The clearance of unchanged phenoperidine in acid urine was significantly greater than in neutral or alkaline urine. By contrast, the elimination of its basic metabolites was enhanced in uncontrolled or alkaline urine. Other pharmacokinetic parameters were not significantly affected.Entities:
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Year: 1983 PMID： 6882616 PMCID： PMC1427958 DOI： 10.1111/j.1365-2125.1983.tb02150.x
Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335