Literature DB >> 6882211

Lethal intoxication with diphenhydramine. Report of a case with analytical follow-up.

E Hausmann, H Wewer, H H Wellhöner, J P Weller.   

Abstract

A fatal monointoxication with diphenhydramine in a male 28 year old is reported. The patient went into hyperpyrexia and tachycardia and died from sudden cardiac arrest. Hemorrhagic pulmonary edema and renal shock were the most prominent pathomorphological findings. At the time of death, the concentration of diphenhydramine was 5 mg/l plasma and was particularly high in the lungs (55 mg/kg) and kidneys (50 mg/kg).

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Year:  1983        PMID: 6882211     DOI: 10.1007/bf01459999

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN: 0340-5761            Impact factor:   5.153


  17 in total

1.  A case of acute diphenhydramine hydrochloride poisoning.

Authors:  F E AARON
Journal:  Br Med J       Date:  1953-07-04

2.  The toxic effects of antihistaminic drugs.

Authors:  J B WYNGAARDEN; M H SEEVERS
Journal:  J Am Med Assoc       Date:  1951-02-03

3.  Danger with benadryl of self medication and large dosage.

Authors:  M C BORMAN
Journal:  J Am Med Assoc       Date:  1947-02-08

4.  Simultaneous identification and quantitation of diphenhydramine and methaqualone.

Authors:  K W Hindmarsh; N W Hamon; D F LeGatt
Journal:  Clin Toxicol       Date:  1977-09       Impact factor: 4.467

5.  Antihistamine toxicity in children.

Authors:  A Reyes-Jacang; J E Wenzl
Journal:  Clin Pediatr (Phila)       Date:  1969-05       Impact factor: 1.168

6.  Toxic psychosis due to diphenhydramine hydrochloride.

Authors:  S A Nigro
Journal:  JAMA       Date:  1968-01-22       Impact factor: 56.272

7.  Diphenhydramine hydrochloride intoxication.

Authors:  H E Hestand; D W Teske
Journal:  J Pediatr       Date:  1977-06       Impact factor: 4.406

8.  Determination of diphenhydramine in plasma by gas chromatography.

Authors:  K S Albert; E Sakmar; J A Morais; M R Hallmark; J G Wagner
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1974-01

9.  Diphenhydramine (benadryl) and tripelennamine (pyribenzamine) intoxication in children.

Authors:  D J JUDGE; K W DUMARS
Journal:  AMA Am J Dis Child       Date:  1953-05

10.  Treatment of acute benadryl (diphenhydramine hydrochloride) intoxication with severe central nervous system changes and recovery.

Authors:  T E REICHELDERFER; S LIVINGSTON; R M AULD; J L PECK
Journal:  J Pediatr       Date:  1955-03       Impact factor: 4.406

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  2 in total

1.  Toxicological identification of diphenhydramine (DPH) in suicide.

Authors:  Lena Eckes; Michael Tsokos; Sieglinde Herre; René Gapert; Sven Hartwig
Journal:  Forensic Sci Med Pathol       Date:  2012-10-12       Impact factor: 2.007

2.  [Detection of diphenhydramine in autolytic brain tissue in poison-induced brain death syndrome].

Authors:  W Vycudilik; S Pollak
Journal:  Z Rechtsmed       Date:  1985
  2 in total

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