Literature DB >> 6879196

Aged rats: recovery of motor impairments by intrastriatal nigral grafts.

N H Gage, S B Dunnett, U Stenevi, A Björklund.   

Abstract

Dissociated cell suspensions, prepared from the substantia nigra and septal regions of rat embryos, can be grafted to the depths of the caudate-putamen and hippocampus of aged rats. The grafts were rich in dopamine-containing and acetylcholinesterase-positive neurons and had produced extensive new dopaminergic and cholinergic terminal networks in the host neostriatum and hippocampus, respectively. The intrastriatal dopaminergic grafts were associated with a significant improvement in motor coordination in the aged rats. This result suggests that the intracerebral grafting technique may provide a new tool for exploring the role of dopaminergic and cholinergic deficits in the neurological and behavioral impairments associated with aging.

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Year:  1983        PMID： 6879196     DOI： 10.1126/science.6879196

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  12 in total

Review 1.  Presynaptic regulation of dopaminergic transmission in the striatum.

Authors:  J Glowinski; A Chéramy; R Romo; L Barbeito
Journal:  Cell Mol Neurobiol       Date:  1988-03       Impact factor: 5.046

2.  Defective motor behavior and neural gene expression in RIIbeta-protein kinase A mutant mice.

Authors:  E P Brandon; S F Logue; M R Adams; M Qi; S P Sullivan; A M Matsumoto; D M Dorsa; J M Wehner; G S McKnight; R L Idzerda
Journal:  J Neurosci       Date:  1998-05-15       Impact factor: 6.167

3.  Implantation of neuronal suspensions into contusive injury sites in the adult rat spinal cord.

Authors:  D W Hoovler; J R Wrathall
Journal:  Acta Neuropathol       Date:  1991       Impact factor: 17.088

4.  Diminished viability, growth, and behavioral efficacy of fetal dopamine neuron grafts in aging rats with long-term dopamine depletion: an argument for neurotrophic supplementation.

Authors:  T J Collier; C E Sortwell; B F Daley
Journal:  J Neurosci       Date:  1999-07-01       Impact factor: 6.167

5.  Cross-species neural transplants of embryonic septal nuclei to the hippocampal formation of adult rats.

Authors:  J K Daniloff; W C Low; R P Bodony; J Wells
Journal:  Exp Brain Res       Date:  1985       Impact factor: 1.972

6.  Transmitter expression and morphological development of embryonic medullary and mesencephalic raphé neurones after transplantation to the adult rat central nervous system. I. Grafts to the spinal cord.

Authors:  G A Foster; M Schultzberg; F H Gage; A Björklund; T Hökfelt; H Nornes; A C Cuello; A A Verhofstad; T J Visser
Journal:  Exp Brain Res       Date:  1985       Impact factor: 1.972

7.  Aging of the striatum: mechanisms and interventions.

Authors:  Hiroyuki Umegaki; George S Roth; Donald K Ingram
Journal:  Age (Dordr)       Date:  2008-07-03

8.  Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.

Authors:  L R Williams; S Varon; G M Peterson; K Wictorin; W Fischer; A Bjorklund; F H Gage
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

9.  Transmitter expression and morphological development of embryonic medullary and mesencephalic raphé neurones after transplantation to the adult rat central nervous system. II. Grafts to the hippocampus.

Authors:  G A Foster; M Schultzberg; F H Gage; A Björklund; T Hökfelt; A C Cuello; A A Verhofstad; T J Visser; P C Emson
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

10.  Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release.

Authors:  P Brundin; R E Strecker; H Widner; D J Clarke; O G Nilsson; B Astedt; O Lindvall; A Björklund
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972
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