Literature DB >> 687828

Absence of beta mRNA in beta0-thalassemia in Kurdish Jews.

F Ramirez, D Starkman, A Bank, H Kerem, G Cividalli, E A Rachmilewitz.   

Abstract

We report the characterization of the amount of beta mRNA in a Kurdish Jewish population with beta0-thalassemia using the same methods employed for characterization of the Catania and Ferrara beta0 patients. We found very low amounts of beta mRNA sequences, consistent with the presence of beta0-thalassemia of the beta mRNA-negative population type. In addition, no globin gene deletion was detected that could account for the absence of beta mRNA.

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Year:  1978        PMID： 687828

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  8 in total

1.  Defects in DNA and globin messenger RNA in homozygotes for hemoglobin Lepore.

Authors:  F Ramirez; J G Mears; U Nudel; A Bank; L Luzzatto; G DiPrisco; R D'Avino; G Pepe; L Camardella; R Gambino; R Cimino; N Quattrin
Journal:  J Clin Invest       Date:  1979-04       Impact factor: 14.808

2.  A new polymorphism in the human beta-globin gene useful in antenatal diagnosis.

Authors:  M C Driscoll; M Baird; A Bank; E A Rachmilewitz
Journal:  J Clin Invest       Date:  1981-10       Impact factor: 14.808

Review 3.  The thalassemias: molecular mechanisms of human genetic disease.

Authors:  R A Spritz; B G Forget
Journal:  Am J Hum Genet       Date:  1983-05       Impact factor: 11.025

4.  mRNA-deficient beta o-thalassemia results from a single nucleotide deletion.

Authors:  A J Kinniburgh; L E Maquat; T Schedl; E Rachmilewitz; J Ross
Journal:  Nucleic Acids Res       Date:  1982-09-25       Impact factor: 16.971

5.  Partial deletion of beta-globin gene DNA in certain patients with beta 0-thalassemia.

Authors:  S H Orkin; J M Old; D J Weatherall; D G Nathan
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

Review 6.  The molecular basis of disorders of human hemoglobin synthesis.

Authors:  F Ramirez; J G Mears; A Bank
Journal:  Mol Cell Biochem       Date:  1980-08-16       Impact factor: 3.396

7.  Similar levels of mRNA from the W1282X and the delta F508 cystic fibrosis alleles, in nasal epithelial cells.

Authors:  T Shoshani; E Kerem; A Szeinberg; A Augarten; Y Yahav; D Cohen; J Rivlin; A Tal; B Kerem
Journal:  J Clin Invest       Date:  1994-04       Impact factor: 14.808

8.  Novel metabolism of several beta zero-thalassemic beta-globin mRNAs in the erythroid tissues of transgenic mice.

Authors:  S Lim; J J Mullins; C M Chen; K W Gross; L E Maquat
Journal:  EMBO J       Date:  1989-09       Impact factor: 11.598
  8 in total

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