Literature DB >> 6877353

mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification.

M Kaartinen, G M Griffiths, A F Markham, C Milstein.   

Abstract

Light and heavy chain mRNAs of 15 anti-oxazolone antibodies were sequenced directly using synthetic primers. Hybridomas obtained 7 days after primary immunization show that they are of restricted heterogeneity. The majority expressed a single sequence with minor differences concentrated in the D region and joining boundaries D--JH and V kappa--J kappa.

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Year:  1983        PMID： 6877353     DOI： 10.1038/304320a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  69 in total

Review 1.  Altered spectra of hypermutation in DNA repair-deficient mice.

Authors:  D B Winter; P J Gearhart
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-01-29       Impact factor: 6.237

2.  Recruitment of a distinct but related set of VH sequences into the murine CD21hi/CD23- marginal zone B cell repertoire to that seen in the class-switched antibody response.

Authors:  Henry N White; Qing-Hai Meng
Journal:  J Immunol       Date:  2011-12-02       Impact factor: 5.422

3.  Mutation and selection during the secondary response to 2-phenyloxazolone.

Authors:  C Rada; S K Gupta; E Gherardi; C Milstein
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

4.  Molecular analysis of antigen recognition by insulin-specific T-cell hybridomas from B6 wild-type and bm12 mutant mice.

Authors:  D H Sherman; P S Hochman; R Dick; R Tizard; K L Ramachandran; R A Flavell; B T Huber
Journal:  Mol Cell Biol       Date:  1987-05       Impact factor: 4.272

5.  Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region.

Authors:  A M Giusti; N C Chien; D J Zack; S U Shin; M D Scharff
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

6.  V kappa and J kappa gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regions.

Authors:  I Sanz; J D Capra
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

7.  Adult B-cell repertoire is biased toward two heavy-chain variable-region genes that rearrange frequently in fetal pre-B cells.

Authors:  A M Lawler; P S Lin; P J Gearhart
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

8.  Molecular dissection of the murine antibody response to streptococcal group A carbohydrate.

Authors:  C T Lutz; T L Bartholow; N S Greenspan; R J Fulton; W J Monafo; R M Perlmutter; H V Huang; J M Davie
Journal:  J Exp Med       Date:  1987-02-01       Impact factor: 14.307

9.  Diversity at the variable-joining region boundary of lambda light chains has a pronounced effect on immunoglobulin ligand-binding activity.

Authors:  T Azuma; V Igras; E B Reilly; H N Eisen
Journal:  Proc Natl Acad Sci U S A       Date:  1984-10       Impact factor: 11.205

10.  Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjögren's syndrome.

Authors:  D I Stott; F Hiepe; M Hummel; G Steinhauser; C Berek
Journal:  J Clin Invest       Date:  1998-09-01       Impact factor: 14.808
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