Literature DB >> 6877116

"Is magnesium depletion the reason for ototoxicity caused by aminoglycosides?".

E Dolev, A Tamir, G Leventon.   

Abstract

Aminoglycoside antibiotic drugs may cause ototoxicity and nephrotoxicity. Our hypothesis postulates that aminoglycosides cause ototoxicity by a mechanism of magnesium depletion in the hair cells of the cochlea. The same mechanism maybe responsible for nephrotoxicity caused by aminoglycosides.

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Year:  1983        PMID： 6877116     DOI： 10.1016/0306-9877(83)90002-6

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN： 0306-9877            Impact factor:   1.538


  3 in total

1.  Transtympanic administration of aminoglycosides in patients with Menière's disease.

Authors:  T Sala
Journal:  Arch Otorhinolaryngol       Date:  1988

2.  Experimental investigations on the influence of anemia on gentamicin ototoxicity.

Authors:  W Delb; A Koch; P Federspil
Journal:  Eur Arch Otorhinolaryngol       Date:  1991       Impact factor: 2.503

3.  Analysis of risk factors for cisplatin-induced ototoxicity in patients with testicular cancer.

Authors:  C Bokemeyer; C C Berger; J T Hartmann; C Kollmannsberger; H J Schmoll; M A Kuczyk; L Kanz
Journal:  Br J Cancer       Date:  1998-04       Impact factor: 7.640
  3 in total

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