Literature DB >> 6877040

Lipid composition and de novo lipid biosynthesis of human palmar fat in Dupuytren's disease.

J L Rabinowitz, L Ostermann, F W Bora, J Staeffen.   

Abstract

Seventy-two surgically obtained Dupuytren's disease palmar-fat (DDPF) specimens and 18 location-matched specimens from patients not suffering from this disease (controls) were studied for their total lipid composition and de novo lipogenic activity. Incubation of "DDPF" with 1-[14C]acetate in oxygen produced [14C]palmitate and [14C]stearate in approximately equal yields as those obtained from "controls." No [14C]octanate was formed in any of the palmar-fat preparations. The lipids and fatty acid analysis revealed differences: (a) DDPF specimens were richer in free fatty acids, methyl esters of fatty acids and free-cholesterol than specimens of controls. (b) DDPF specimens contained less phospholipids. (c) DDPF specimens showed a significantly higher content of octanoate and other short-chain fatty acids than specimens of controls. The above findings are not incompatible with the results expected if some mild hypoxia occurred in DDPF; this has been suggested in the statistical correlations observed for this disease and alcoholism with liver involvement.

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Year:  1983        PMID： 6877040     DOI： 10.1007/bf02537234

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  19 in total

1.  Determination of serum proteins by means of the biuret reaction.

Authors:  A G GORNALL; C J BARDAWILL; M M DAVID
Journal:  J Biol Chem       Date:  1949-02       Impact factor: 5.157

2.  The effects of intravenous sodium octanoate on the rhesus monkey.

Authors:  J L Rabinowitz; J Staeffen; P Aumonier; P Blanquet; J D Vincent; R Daviaud; P Ballan; J Ferrer; R Terme; C Series; R M Myerson
Journal:  Am J Gastroenterol       Date:  1978-02       Impact factor: 10.864

3.  Polar and neutral lipids of pig gingiva.

Authors:  J L Rabinowitz; T A Bailey; J B Marsh
Journal:  Arch Oral Biol       Date:  1971-10       Impact factor: 2.633

4.  Synergism between ammonia and fatty acids in the production of coma: implications for hepatic coma.

Authors:  F J Zieve; L Zieve; W M Doizaki; R B Gilsdorf
Journal:  J Pharmacol Exp Ther       Date:  1974-10       Impact factor: 4.030

5.  Incomplete oxidation of palmitate and leakage of intermediary products during anoxia.

Authors:  J L Rabinowitz; E S Hercker
Journal:  Arch Biochem Biophys       Date:  1974-04-02       Impact factor: 4.013

6.  Synergism between mercaptans and ammonia or fatty acids in the production of coma: a possible role for mercaptans in the pathogenesis of hepatic coma.

Authors:  L Zieve; W M Doizaki; J Zieve
Journal:  J Lab Clin Med       Date:  1974-01

7.  Volatile fatty acids in the breath of patients with cirrhosis of the liver.

Authors:  S Chen; V Mahadevan; L Zieve
Journal:  J Lab Clin Med       Date:  1970-04

8.  Biochemistry and histology of the connective tissue of Dupuytren's disease lesions.

Authors:  S Bazin; M Le Lous; V C Duance; T J Sims; A J Bailey; G Gabbiani; G D'Andiran; G Pizzolato; A Browski; C Nicoletis; A Delaunay
Journal:  Eur J Clin Invest       Date:  1980-02       Impact factor: 4.686

9.  A method for serum octanoate in hepatic cirrhosis and hepatic encephalopathy.

Authors:  J L Rabinowitz; J Staeffen; P Aumonier; P Ballan; J Ferrer; R Terme; C Series; R M Myerson
Journal:  Clin Chem       Date:  1977-12       Impact factor: 8.327

10.  Lipid composition and biosynthesis of human omental tissue.

Authors:  J I Rabinowitz; S E Askins; F E Luddy
Journal:  Lipids       Date:  1978-05       Impact factor: 1.880
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  9 in total

1.  Free radicals and Dupuytren's contracture.

Authors:  G A Murrell; M J Francis; L Bromley
Journal:  Br Med J (Clin Res Ed)       Date:  1987-11-28

2.  Identification of mesenchymal stem cells in perinodular fat and skin in Dupuytren's disease: a potential source of myofibroblasts with implications for pathogenesis and therapy.

Authors:  Syed Amir Iqbal; Christopher Manning; Farhatullah Syed; Venkatesh Kolluru; Mike Hayton; Stewart Watson; Ardeshir Bayat
Journal:  Stem Cells Dev       Date:  2011-07-19       Impact factor: 3.272

Review 3.  The role of the skin in Dupuytren's disease.

Authors:  J Hueston
Journal:  Ann R Coll Surg Engl       Date:  1985-11       Impact factor: 1.891

4.  An insight into Dupuytren's contracture.

Authors:  G A Murrell
Journal:  Ann R Coll Surg Engl       Date:  1992-05       Impact factor: 1.891

Review 5.  Scientific understanding and clinical management of Dupuytren disease.

Authors:  Barbara Shih; Ardeshir Bayat
Journal:  Nat Rev Rheumatol       Date:  2010-11-09       Impact factor: 20.543

6.  Differential gene expression analysis of subcutaneous fat, fascia, and skin overlying a Dupuytren's disease nodule in comparison to control tissue.

Authors:  Barbara Shih; Jason J Brown; Daniel J Armstrong; Tommy Lindau; Ardeshir Bayat
Journal:  Hand (N Y)       Date:  2009-01-29

7.  Dupuytren's contracture and alcohol.

Authors:  A Bradlow; A G Mowat
Journal:  Ann Rheum Dis       Date:  1986-04       Impact factor: 19.103

8.  Metabolic factors and the risk of Dupuytren's disease: data from 30,000 individuals followed for over 20 years.

Authors:  Mattias Rydberg; Malin Zimmerman; Jin Persson Löfgren; Anders Gottsäter; Peter M Nilsson; Olle Melander; Lars B Dahlin
Journal:  Sci Rep       Date:  2021-07-19       Impact factor: 4.379

9.  First identification of resident and circulating fibrocytes in Dupuytren's disease shown to be inhibited by serum amyloid P and Xiapex.

Authors:  Syed Amir Iqbal; Michael John Hayton; James Stewart Watson; Piotr Szczypa; Ardeshir Bayat
Journal:  PLoS One       Date:  2014-06-16       Impact factor: 3.240
  9 in total

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