Literature DB >> 6876079

Synthesis and antibacterial activity of some 3-[(alkylthio)methyl]quinoxaline 1-oxide derivatives.

J P Dirlam, J E Presslitz, B J Williams.   

Abstract

Some 3-[(alkylthio)methyl]quinoxaline 1-oxide derivatives (1) have been synthesized and screened for antibacterial activity. 2-Acetyl-3-[(methylsulfonyl)methyl]quinoxaline 1-oxide (7a) was found to possess good in vitro activity against some pathogens important to veterinary medicine including Treponema hyodysenteriae, a causative agent in swine dysentery. In an in vivo experiment, this compound (7a) completely protected pigs against a swine dysentery challenge over a 21-day period.

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Year:  1983        PMID： 6876079     DOI： 10.1021/jm00362a007

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  6 in total

1.  Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis.

Authors:  Sidharth Chopra; Gary A Koolpe; Arlyn A Tambo-Ong; Karen N Matsuyama; Kenneth J Ryan; Tran B Tran; Rupa S Doppalapudi; Edward S Riccio; Lalitha V Iyer; Carol E Green; Baojie Wan; Scott G Franzblau; Peter B Madrid
Journal:  J Med Chem       Date:  2012-06-25       Impact factor: 7.446

Review 2.  New small-molecule synthetic antimycobacterials.

Authors:  Lluis Ballell; Robert A Field; Ken Duncan; Robert J Young
Journal:  Antimicrob Agents Chemother       Date:  2005-06       Impact factor: 5.191

3.  Synthesis of quinoxaline 1,4-di-N-oxide analogues and crystal structure of 2-carbomethoxy-3-hydroxyquinoxaline-di-N-oxide.

Authors:  Yingjun Xu; Fanhong Wu; Zhiyi Yao; Minmin Zhang; Sheng Jiang
Journal:  Molecules       Date:  2011-08-12       Impact factor: 4.411

4.  Dichotomy of platinum(II) and gold(III) carbene intermediates switching from N- to O-selectivity.

Authors:  Hongming Jin; Wen-Yan Tong; Jing Zhang; Matthias Rudolph; Frank Rominger; Xu Shen; Shuanglin Qu; A Stephen K Hashmi
Journal:  Nat Commun       Date:  2022-03-30       Impact factor: 14.919

Review 5.  Recent advances in the transition-metal-free synthesis of quinoxalines.

Authors:  Biplob Borah; L Raju Chowhan
Journal:  RSC Adv       Date:  2021-11-19       Impact factor: 4.036

6.  Synthesis, in vitro Anticancer and Antimicrobial Evaluation of Novel Substituted Dihydropyrimidines.

Authors:  K Rana; A Arora; S Bansal; R Chawla
Journal:  Indian J Pharm Sci       Date:  2014-07       Impact factor: 0.975
  6 in total

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