| Literature DB >> 6876078 |
R D Titus, E C Kornfeld, N D Jones, J A Clemens, E B Smalstig, R W Fuller, R A Hahn, M D Hynes, N R Mason, D T Wong, M M Foreman.
Abstract
The title compound (+/-)-5 (R = Pro) (LY141865) has been resolved into a (-) isomer and a (+) isomer as the D- and L-tartrate salts, respectively. Biological studies have shown that dopamine agonist activity is a property of only the (-) isomer. Crystallographic analysis has proven that the absolute configuration of the active (-) isomer is the same as that of the natural ergolines.Entities:
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Year: 1983 PMID： 6876078 DOI： 10.1021/jm00362a005
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446