Literature DB >> 6875576

Plant anticancer agents. XXIII. 6 alpha-senecioyloxychaparrin, a new antileukemic quassinoid from Simaba multiflora.

M Arisawa, A D Kinghorn, G A Cordell, N R Farnsworth.   

Abstract

Fractionation of an aqueous ethanol extract of the wood of Simaba multiflora afforded a new antineoplastic quassinoid, 6 alpha-senecioyloxychaparrin (5), and two known quassinoids 6 alpha-senecioyloxychaparrinone (1) and chaparrinone (2). The structure of 5, which displayed activity against the KB and P-388 test systems, was established through the interpretation of spectral data.

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Year:  1983        PMID： 6875576     DOI： 10.1021/np50026a015

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  2 in total

1.  Growth inhibitory, insecticidal and antifeedant effects of some antileukemic and cytotoxic quassinoids on two species of agricultural pests.

Authors:  J A Klocke; M Arisawa; S S Handa; A D Kinghorn; G A Cordell; N R Farnsworth
Journal:  Experientia       Date:  1985-03-15

2.  Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition.

Authors:  John A Beutler; Moon-Il Kang; Francis Robert; Jason A Clement; Jerry Pelletier; Nancy H Colburn; Tawnya C McKee; Ekaterina Goncharova; James B McMahon; Curtis J Henrich
Journal:  J Nat Prod       Date:  2009-03-27       Impact factor: 4.050
  2 in total

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