Literature DB >> 6874826

Analysis and quantitation of a metabolite of doxycycline in mice, rats, and humans by high-performance liquid chromatography.

R Böcker.   

Abstract

A metabolite of doxycycline has not previously been isolated. In this paper it is demonstrated that doxycycline is metabolized in mice, rats, and humans. By means of high-performance liquid chromatography and consecutive gel chromatography one metabolite of doxycycline was isolated from animal organs and human urine. The metabolite was tentatively identified as N-monodemethyldoxycycline by mass spectral and spectrophotometric analyses. The rate of metabolism could be enhanced by pretreatment of the animals with phenobarbital, an inducing agent of the drug-metabolizing enzymes.

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Year:  1983        PMID： 6874826     DOI： 10.1016/s0378-4347(00)84428-x

Source DB:  PubMed          Journal:  J Chromatogr


  6 in total

1.  Genetic dissection of the circuit for hand dexterity in primates.

Authors:  Masaharu Kinoshita; Ryosuke Matsui; Shigeki Kato; Taku Hasegawa; Hironori Kasahara; Kaoru Isa; Akiya Watakabe; Tetsuo Yamamori; Yukio Nishimura; Bror Alstermark; Dai Watanabe; Kazuto Kobayashi; Tadashi Isa
Journal:  Nature       Date:  2012-07-12       Impact factor: 49.962

2.  Preclinical Efficacy and Safety Profile of Allometrically Scaled Doses of Doxycycline Used to Turn "On" Therapeutic Transgene Expression from High-Capacity Adenoviral Vectors in a Glioma Model.

Authors:  Nathan VanderVeen; Nicholas Raja; Elizabeth Yi; Henry Appelman; Philip Ng; Donna Palmer; Daniel Zamler; Marta Dzaman; Pedro R Lowenstein; Maria G Castro
Journal:  Hum Gene Ther Methods       Date:  2016-04-28       Impact factor: 2.396

3.  Significant intestinal excretion, one source of variability in pharmacokinetics of COL-3, a chemically modified tetracycline.

Authors:  Jing Li; Shufeng Zhou; Hung Huynh; Eli Chan
Journal:  Pharm Res       Date:  2005-03       Impact factor: 4.200

4.  A novel and rapid method to determine doxycycline in human plasma by liquid chromatography tandem mass spectrometry.

Authors:  A Chaitanya Krishna; M Sathiyaraj; R S Saravanan; R Chelladurai; R Vignesh
Journal:  Indian J Pharm Sci       Date:  2012-11       Impact factor: 0.975

5.  Pharmacokinetics of an injectable long-acting formulation of doxycycline hyclate in dogs.

Authors:  Lilia Gutiérrez; Zazil-Ha Velasco; Carlos Vázquez; Dinorah Vargas; Héctor Sumano
Journal:  Acta Vet Scand       Date:  2012-06-08       Impact factor: 1.695

6.  Marmosets as a preclinical model for testing "off-label" use of doxycycline to turn on Flt3L expression from high-capacity adenovirus vectors.

Authors:  Nathan VanderVeen; Christopher Paran; Ashley Appelhans; Johnny Krasinkiewicz; Rosemary Lemons; Henry Appelman; Robert Doherty; Donna Palmer; Philip Ng; Pedro R Lowenstein; Maria G Castro
Journal:  Mol Ther Methods Clin Dev       Date:  2014-02-05       Impact factor: 6.698
  6 in total

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