Literature DB >> 6874585

Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization.

T Hamamoto, S Gunji, H Tsuji, T Beppu.   

Abstract

A strain of Streptomyces was found to produce new antifungal antibiotics. The active compounds were purified and separated into two substances named leptomycin A and B by high performance liquid chromatography. The molecular formulae of leptomycins A and B are C32H46O6 and C33H48O6 respectively, and physicochemical and biological properties of them are very similar to each other. Leptomycins A and B exhibit strong inhibitory activity against Schizosaccharomyces and Mucor.

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Year:  1983        PMID： 6874585     DOI： 10.7164/antibiotics.36.639

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  33 in total

1.  A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export.

Authors:  Dirk Daelemans; Elena Afonina; Jakob Nilsson; Gudrun Werner; Jorgen Kjems; Erik De Clercq; George N Pavlakis; Anne-Mieke Vandamme
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-09       Impact factor: 11.205

2.  Nuclear translocation of anamorsin during drug-induced dopaminergic neurodegeneration in culture and in rat brain.

Authors:  Kyung-Ah Park; Nuri Yun; Dong-Ik Shin; So Yoen Choi; Hyun Kim; Won-Ki Kim; Yuzuru Kanakura; Hirohiko Shibayama; Young J Oh
Journal:  J Neural Transm (Vienna)       Date:  2010-10-06       Impact factor: 3.575

3.  Uncapped mRNA introduced into tobacco protoplasts can be imported into the nucleus and is trapped by leptomycin B.

Authors:  Rogier Stuger; Christoph Forreiter
Journal:  Plant Cell Rep       Date:  2004-06-24       Impact factor: 4.570

4.  The CRM1 nuclear export protein in normal development and disease.

Authors:  Kevin T Nguyen; Michael P Holloway; Rachel A Altura
Journal:  Int J Biochem Mol Biol       Date:  2012-05-18

5.  Structure-based design of a pathway-specific nuclear import inhibitor.

Authors:  Ahmet E Cansizoglu; Brittany J Lee; Zi Chao Zhang; Beatriz M A Fontoura; Yuh Min Chook
Journal:  Nat Struct Mol Biol       Date:  2007-04-15       Impact factor: 15.369

6.  The cellular localization pattern of Varicella-Zoster virus ORF29p is influenced by proteasome-mediated degradation.

Authors:  Christina L Stallings; Gregory J Duigou; Anne A Gershon; Michael D Gershon; Saul J Silverstein
Journal:  J Virol       Date:  2006-02       Impact factor: 5.103

7.  Microbial conversion products of leptomycin B.

Authors:  M Kuhnt; F Bitsch; M Ponelle; J J Sanglier; Y Wang; B Wolff
Journal:  Appl Environ Microbiol       Date:  1998-02       Impact factor: 4.792

8.  In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI-940 and its hydroxy analog (PD 114,721).

Authors:  B J Roberts; K L Hamelehle; J S Sebolt; W R Leopold
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

9.  Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry.

Authors:  Ketan Thakar; Samir Karaca; Sarah A Port; Henning Urlaub; Ralph H Kehlenbach
Journal:  Mol Cell Proteomics       Date:  2012-12-13       Impact factor: 5.911

10.  SUMOylation regulates nuclear localization of Krüppel-like factor 5.

Authors:  James X Du; Agnieszka B Bialkowska; Beth B McConnell; Vincent W Yang
Journal:  J Biol Chem       Date:  2008-09-09       Impact factor: 5.157
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