Literature DB >> 6874563

DC-52, a novel antitumor antibiotic. 2. Isolation, physico-chemical characteristics and structure determination.

K Takahashi, F Tomita.   

Abstract

DC-52, C18H22N2O4, is a new antitumor antibiotic produced by Streptomyces melanovinaceus nov. sp. The structure of DC-52 has been determined by consideration of spectral data. It has the novel skeleton, 8,11-iminoazepinoisoquinoline.

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Year:  1983        PMID： 6874563     DOI： 10.7164/antibiotics.36.468

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  8 in total

1.  Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy.

Authors:  Qin Zang; Salim Javed; Patrick Porubsky; Farman Ullah; Benjamin Neuenswander; Gerald H Lushington; Fatima Z Basha; Michael G Organ; Paul R Hanson
Journal:  ACS Comb Sci       Date:  2012-02-06       Impact factor: 3.784

2.  Disposition of DX-52-1, a novel anticancer agent, after intravenous administration to mice and dogs.

Authors:  E Fuse; H Nishiie; H Kobayashi; S Ikeda; H Saito; J Covey; S Kobayashi
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1997 Jan-Mar       Impact factor: 2.441

Review 3.  Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics.

Authors:  V H Le; M Inai; R M Williams; T Kan
Journal:  Nat Prod Rep       Date:  2015-02       Impact factor: 13.423

4.  Antitumor activities of KW-2152, a new isoquinon agent, against human tumor xenografts transplanted into nude mice.

Authors:  Y Nosoh; M Nishiyama; K Niimi; N Hirabayashi; T Toge; M Niimoto; T Hattori
Journal:  Jpn J Surg       Date:  1987-03

5.  Computer simulation of the binding of quinocarcin to DNA. Prediction of mode of action and absolute configuration.

Authors:  G C Hill; T P Wunz; W A Remers
Journal:  J Comput Aided Mol Des       Date:  1988-07       Impact factor: 3.686

6.  Synthetic studies on lemonomycin: construction of the tetracyclic core.

Authors:  Alberto Jiménez-Somarribas; Robert M Williams
Journal:  Tetrahedron       Date:  2013-09-02       Impact factor: 2.457

7.  The mechanism of action of quinocarmycin citrate (KW 2152) on mouse L1210 cells in vitro.

Authors:  R Kanamaru; Y Konishi; C Ishioka; H Kakuta; T Sato; A Ishikawa; M Asamura; A Wakui
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333

Review 8.  Application of the Asymmetric Pictet-Spengler Reaction in the Total Synthesis of Natural Products and Relevant Biologically Active Compounds.

Authors:  Majid M Heravi; Vahideh Zadsirjan; Masumeh Malmir
Journal:  Molecules       Date:  2018-04-18       Impact factor: 4.411
  8 in total

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