Monoclonal antibodies to rat sarcomata. II. A syngeneic IgG2b antibody with anti-tumour activity.

The IgG2b monoclonal antibody M10/76, which is specific for the Hooded rat fibrosarcoma MC24, was obtained by fusion of the rat myeloma Y3 Ag 1.2.3 with spleen cells from an MC24 tumour-bearing rat. This antibody has been found to inhibit lung colonization when MC24 cells were injected i.v. into Hooded rats, and when passively transferred into athymic MC24 tumour bearers, it prevented or considerably reduced the incidence of spontaneous lung metastases in more than half the treated animals.