Literature DB >> 6873304

Neurotensin modulates human neutrophil locomotion and phagocytic capability.

R Goldman, Z Bar-Shavit, D Romeo.   

Abstract

Neurotensin (NT) was found to induce oriented locomotion and augment the phagocytic capability of human blood neutrophils over 10(-11) - 10(-7) M. The tridecapeptide also causes Ca2+ extrusion from neutrophils, very likely as a result of intracellular Ca2+ mobilization. It is suggested that the NT-mediated functional modulation of neutrophils correlates with the capacity of NT to affect the intracellular compartmentalization of Ca2+. Peripheral NT-elicited phenomena such as vasodilation, enhanced vascular compartmentalization of Ca2+. Peripheral NT-elicited phenomena such as vasodilation, enhanced vascular permeability, mast cell degranulation and the enhancement of directional migration and phagocytosis of neutrophils described here, classify NT as a typical mediator of inflammation.

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Year:  1983        PMID： 6873304     DOI： 10.1016/0014-5793(83)80417-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Absence of neurotensin attenuates intestinal dysbiosis and inflammation by maintaining Mmp7/α-defensin axis in diet-induced obese mice.

Authors:  Jing Li; Xian Li; Jun Song; Baoxiang Yan; Stephanie A Rock; Jianhang Jia; Jinpeng Liu; Chi Wang; Todd Weiss; Heidi L Weiss; Tianyan Gao; Ashfaqul Alam; B Mark Evers
Journal:  FASEB J       Date:  2020-05-02       Impact factor: 5.191

Review 2.  The role of neurotensin in central nervous system pathophysiology: what is the evidence?

Authors:  Fannie St-Gelais; Claudia Jomphe; Louis-Eric Trudeau
Journal:  J Psychiatry Neurosci       Date:  2006-07       Impact factor: 6.186

3.  Modulation of phagocytic function in murine peritoneal macrophages by bombesin, gastrin-releasing peptide and neuromedin C.

Authors:  M De la Fuente; M Del Rio; M D Ferrandez; A Hernanz
Journal:  Immunology       Date:  1991-06       Impact factor: 7.397

Review 4.  Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity.

Authors:  J J Worthington; F Reimann; F M Gribble
Journal:  Mucosal Immunol       Date:  2017-08-30       Impact factor: 7.313

5.  Neurotensin is a proinflammatory neuropeptide in colonic inflammation.

Authors:  I Castagliuolo; C C Wang; L Valenick; A Pasha; S Nikulasson; R E Carraway; C Pothoulakis
Journal:  J Clin Invest       Date:  1999-03       Impact factor: 14.808

6.  Neurotensin decreases the proinflammatory status of human skin fibroblasts and increases epidermal growth factor expression.

Authors:  Lucília Pereira da Silva; Bruno Miguel Neves; Liane Moura; Maria Teresa Cruz; Eugénia Carvalho
Journal:  Int J Inflam       Date:  2014-08-11

Review 7.  New extracellular factors in glioblastoma multiforme development: neurotensin, growth differentiation factor-15, sphingosine-1-phosphate and cytomegalovirus infection.

Authors:  Jan Korbecki; Izabela Gutowska; Ireneusz Kojder; Dariusz Jeżewski; Marta Goschorska; Agnieszka Łukomska; Anna Lubkowska; Dariusz Chlubek; Irena Baranowska-Bosiacka
Journal:  Oncotarget       Date:  2018-01-09

8.  Cannabinoid CB1 Receptors Mediate the Gastroprotective Effect of Neurotensin.

Authors:  Parichehr Hassanzadeh; Elham Arbabi
Journal:  Iran J Basic Med Sci       Date:  2012-05       Impact factor: 2.699
  8 in total

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