Literature DB >> 6873245

The effect of propylthiouracil on glutathione S-transferase activity of rat spleen in vitro and in vivo.

K Kariya, E Lee, T Matsue.   

Abstract

Propylthiouracil (PTU) inhibited glutathione (GSH) S-transferase (EC 2.5.1.18) activity of rat spleens in a concentration dependent manner in vitro. PTU (1.5 mmoles/kg) treatment of rats for 1 or 2 weeks caused a decrease in leukocyte number and spleen weight. Nevertheless, GSH S-transferase activity was not affected by the same treatment.

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Year:  1983        PMID： 6873245     DOI： 10.1007/bf01990426

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

1.  Glutathione S-transferase AA from rat liver.

Authors:  W H Habig; M J Pabst; W B Jakoby
Journal:  Arch Biochem Biophys       Date:  1976-08       Impact factor: 4.013

2.  Glutathione S-transferase A. A novel kinetic mechanism in which the major reaction pathway depends on substrate concentration.

Authors:  M J Pabst; W H Habig; W B Jakoby
Journal:  J Biol Chem       Date:  1974-11-25       Impact factor: 5.157

3.  Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.

Authors:  W H Habig; M J Pabst; W B Jakoby
Journal:  J Biol Chem       Date:  1974-11-25       Impact factor: 5.157

4.  Methimazole toxicity from high doses.

Authors:  J J Wiberg; F Q Nuttall
Journal:  Ann Intern Med       Date:  1972-09       Impact factor: 25.391

5.  Studies on glutathione-S-arene oxidase transferase. A sensitive assay and partial purification of the enzyme from sheep liver.

Authors:  T Hayakawa; R A Lemahieu; S Udenfriend
Journal:  Arch Biochem Biophys       Date:  1974-05       Impact factor: 4.013

Review 6.  Thyroid peroxidase and thyroxine biosynthesis.

Authors:  A Taurog
Journal:  Recent Prog Horm Res       Date:  1970

7.  Granulocytopenia, lupus-like syndrome, and other complications of propylthiouracil therapy.

Authors:  J A Amrhein; F M Kenny; D Ross
Journal:  J Pediatr       Date:  1970-01       Impact factor: 4.406

Review 8.  Toxicology of thiono-sulfur compounds.

Authors:  R A Neal; J Halpert
Journal:  Annu Rev Pharmacol Toxicol       Date:  1982       Impact factor: 13.820

9.  The mechanism of action of the thioureylene antithyroid drugs.

Authors:  A Taurog
Journal:  Endocrinology       Date:  1976-04       Impact factor: 4.736

Review 10.  Regulation of granulocyte and monocyte-macrophage proliferation by colony stimulating factor (CSF): a review.

Authors:  D Metcalf
Journal:  Exp Hematol       Date:  1973       Impact factor: 3.084
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