Literature DB >> 6873244

Low doses of 2,4,5-trichlorophenoxyacetic acid are behaviorally teratogenic to rats.

M A Crampton, L J Rogers.   

Abstract

Pre-natal exposure of rats to 2,4,5-T has long-term effects on behavior. A test for novelty responding detects abnormalities after exposure to a single dose as low as 6 mg/kg on day 8 of gestation. This is well below doses reported to be morphologically teratogenic, and raises concern for human exposure.

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Year:  1983        PMID： 6873244     DOI： 10.1007/bf01990423

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  Jumping chickens: relevance to hazard in humans.

Authors:  L J Rogers; C A Sanderson
Journal:  Science       Date:  1982-03-12       Impact factor: 47.728

2.  Pre- and postnatal studies on 2,4,5-trichlorophenoxyacetic acid, 2,4-dichlorophenoxyacetic acid and their derivatives in rats.

Authors:  K S Khera; W P McKinley
Journal:  Toxicol Appl Pharmacol       Date:  1972-05       Impact factor: 4.219

3.  Field worker exposure and helicopter spray pattern of 2,4,5-T.

Authors:  T L Lavy; J S Shepard; D C Bouchard
Journal:  Bull Environ Contam Toxicol       Date:  1980-01       Impact factor: 2.151

4.  The open field: some comparative data.

Authors:  D K Candland; Z M Nagy
Journal:  Ann N Y Acad Sci       Date:  1969-07-30       Impact factor: 5.691

5.  Two independent behavioral dimensions in open-field performance.

Authors:  A E Whimbey; V H Denenberg
Journal:  J Comp Physiol Psychol       Date:  1967-06

6.  2,4,5-trichlorophenoxyacetic acid causes behavioral effects in chickens at environmentally relevant doses.

Authors:  C A Sanderson; L J Rogers
Journal:  Science       Date:  1981-02-06       Impact factor: 47.728

7.  Three-generation reproduction study of rats given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the diet.

Authors:  F J Murray; F A Smith; K D Nitschke; C G Humiston; R J Kociba; B A Schwetz
Journal:  Toxicol Appl Pharmacol       Date:  1979-09-15       Impact factor: 4.219
  7 in total
  2 in total

1.  Effects of prenatal exposure to 2,4-D/2,4,5-T mixture on postnatal changes in rat brain glutamate, GABA, protein, and nucleic acid levels.

Authors:  F K Mohammad; V E St Omer
Journal:  Bull Environ Contam Toxicol       Date:  1988-02       Impact factor: 2.151

Review 2.  Occupational exposure and defects of the central nervous system in offspring: review.

Authors:  N Roeleveld; G A Zielhuis; F Gabreëls
Journal:  Br J Ind Med       Date:  1990-09
  2 in total

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