A temperature controller for in vitro recording chambers.

An inexpensive, electrically quiet temperature controller designed to provide biological temperatures in chambers used to maintain tissue slices for in vitro recording is described. The circuit incorporates several advantageous features: (1) an integrated circuit temperature sensor is used which produces a linear output and is immune to self-heating error; (2) a single +12-18 V, 1 A DC supply will power the unit; (3) the output regulator cannot be damaged by overheating or short-circuiting; and (4) the temperature of the preparation is displayed.