| Literature DB >> 6871554 |
P D Verdouw, B H Wolffenbuttel.
Abstract
A 10 min ligation of the left anterior descending coronary artery in anaesthetized pigs resulted in ventricular fibrillation (VF) in 70% of control and propranolol-treated animals. Felodipine (10 nmol kg-1) not only reduced ventricular ectopic activity by 90%, but also completely abolished VF. When a second occlusion was applied after 20 min of reperfusion, felodipine was less effective against VF, possibly due to decreasing felodipine concentrations or only a transient increase in VF threshold.Entities:
Mesh：
Substances：
Year: 1983 PMID： 6871554 PMCID： PMC2044831 DOI： 10.1111/j.1476-5381.1983.tb10486.x
Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739