Literature DB >> 68705

The steering function of T cells in expression of the antibody repertoire directed against multideterminant protein antigen.

E Sercarz, J M Cecka, D Kipp, A Miller.   

Abstract

Limitation in the T-cell repertoire has the consequence of reducing the heterogeneity of antibody production. This has been demonstrated in three different systems, in which the T-cell restriction was imposed (1) by tolerance, (2) by peptide priming (3) by natural scarcity. Therefore, expressed repertoires may represent only a portion of the genetically prescribed V regions.

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Year:  1977        PMID： 68705

Source DB:  PubMed          Journal:  Ann Immunol (Paris)        ISSN： 0300-4910


  3 in total

1.  T-B reciprocity. An Ia-restricted epitope-specific circuit regulating T cell-B cell interaction and antibody specificity.

Authors:  J A Berzofsky
Journal:  Surv Immunol Res       Date:  1983

2.  Mechanisms of antigen-specific, genetically restricted, T cell-B cell interaction.

Authors:  J A Berzofsky
Journal:  Surv Immunol Res       Date:  1984

3.  A major anti-myoglobin idiotype. Influence of H-2-linked Ir genes on idiotype expression.

Authors:  H Kawamura; Y Kohno; M Busch; F R Gurd; J A Berzofsky
Journal:  J Exp Med       Date:  1984-09-01       Impact factor: 14.307
  3 in total

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