| Literature DB >> 6870245 |
J D Desai, A J Desai, H C Patel.
Abstract
Addition of biotin to culture medium NL-406 significantly increased alkaloid yield during submerged cultivation of Claviceps sp. strain SD-58. Alkaloid yield was further enhanced by incorporating leucine in biotin-supplemented culture medium. Increased alkaloid production was associated with an increase in the lipid content of cells and in the number of chlamydospores. Biotin deficiency caused a reduction in alkaloid yield and a parallel decrease in lipid content and chlamydospore numbers.Entities:
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Year: 1983 PMID: 6870245 PMCID: PMC242518 DOI: 10.1128/aem.45.5.1694-1696.1983
Source DB: PubMed Journal: Appl Environ Microbiol ISSN: 0099-2240 Impact factor: 4.792