Literature DB >> 686908

Comparative effects of amiodarone, perhexiline and bepridil on the cardiac rhythms of the unanesthetized dog in chronic heart block.

M Boucher, D Duchene-Marullaz.   

Abstract

The effects of amiodarone, perhexiline and bepridil, which decrease effort cardioacceleration although they have no adrenergic beta blocking properties, were studied in the unanesthetized dog in chronic heart block. All three products decreased atrial rate in a durable way after an initial phase of tachycardia. Amiodarone had no depressant effect on idioventricular rate; however, this was significantly slowed by the other two compounds.

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Year:  1978        PMID： 686908

Source DB:  PubMed          Journal:  Arch Int Pharmacodyn Ther        ISSN： 0003-9780


  5 in total

1.  Acute effects of amiodarone upon the canine sinus node and atrioventricular junctional region.

Authors:  H O Gloor; F Urthaler; T N James
Journal:  J Clin Invest       Date:  1983-05       Impact factor: 14.808

2.  Long-term observation of atrial and ventricular rates in the unanesthetized dog with complete atrioventricular block.

Authors:  M Boucher; C Dubray; P Duchene-Marullaz
Journal:  Pflugers Arch       Date:  1982-12       Impact factor: 3.657

3.  Studies on the bradycardia induced by bepridil.

Authors:  M Beaughard; M Ferrier; C Labrid; J C Lamar; J Leboeuf; P Piris
Journal:  Br J Pharmacol       Date:  1982-02       Impact factor: 8.739

Review 4.  Bepridil. A review of its pharmacological properties and therapeutic use in stable angina pectoris.

Authors:  L M Hollingshead; D Faulds; A Fitton
Journal:  Drugs       Date:  1992-11       Impact factor: 9.546

5.  Comparative clinical efficacy of bepridil, propranolol and placebo in patients with chronic stable angina.

Authors:  A P Rae; J M Beattie; T D Lawrie; I Hutton
Journal:  Br J Clin Pharmacol       Date:  1985-03       Impact factor: 4.335
  5 in total

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