Literature DB >> 686795

Successful restoration of immunity in the DiGeorge syndrome with fetal thymic epithelial transplant.

Y H Thong, E F Robertson, H G Rischbieth, G J Smith, G F Binns, K Cheney, A C Pollard.   

Abstract

A 13-month-old girl presented with right upper lobe pneumonia and hypocalcaemic seizures: investigations showed hypoparathyroidism and impaired cell-mediated immune responses. Other features of the DiGeorge syndrome included hypertelorism, short philtrum of the lip, right-sided aortic arch, and aberrant origin of the left subclavian artery. Successful restoration of the immunodeficiency was achieved by transplantation of fetal thymic epithelium.

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Year:  1978        PMID： 686795      PMCID： PMC1544972          DOI： 10.1136/adc.53.7.580

Source DB:  PubMed          Journal:  Arch Dis Child        ISSN： 0003-9888            Impact factor:   3.791


  15 in total

1.  Immunological function of the thymus.

Authors:  J F MILLER
Journal:  Lancet       Date:  1961-09-30       Impact factor: 79.321

2.  Morphological and functional maturation of human thymic epithelium in culture.

Authors:  K W Pyke; E W Gelfand
Journal:  Nature       Date:  1974-10-04       Impact factor: 49.962

3.  Agammaglobulinaemia with B lymphocytes. Specific defect of plasma-cell differentiation.

Authors:  M D Cooper; A R Lawton; D E Bockman
Journal:  Lancet       Date:  1971-10-09       Impact factor: 79.321

4.  Impaired in vitro cell-mediated immunity to rubella virus during pregnancy.

Authors:  Y H Thong; R W Steele; M M Vincent; S A Hensen; J A Bellanti
Journal:  N Engl J Med       Date:  1973-09-20       Impact factor: 91.245

5.  Foetal thymic transplant in a case of Digeorge's syndrome.

Authors:  W W Cleveland; B J Fogel; W T Brown; H E Kay
Journal:  Lancet       Date:  1968-12-07       Impact factor: 79.321

6.  Implantation of a foetal thymus, restoring immunological competence in a patient with thymic aplasia (Digeorge's syndrome).

Authors:  C S August; F S Rosen; R M Filler; C A Janeway; B Markowski; H E Kay
Journal:  Lancet       Date:  1968-12-07       Impact factor: 79.321

7.  Thymus transplantation. Permanent reconstitution of cellular immunity in a patient with sex-linked combined immunodeficiency.

Authors:  A J Ammann; D W Wara; S Salmon; H Perkins
Journal:  N Engl J Med       Date:  1973-07-05       Impact factor: 91.245

8.  T-lymphocyte differentiation in vitro in primary immunodeficiency diseases.

Authors:  J L Touraine; G S Incefy; F Touraine; P L'Esperance; F P Siegal; R A Good
Journal:  Clin Immunol Immunopathol       Date:  1974-11

9.  Thymosin-induced human serum factor increasing cyclic AMP.

Authors:  A Astaldi; G C Astaldi; P Wijermans; M Groenewoud; P T Schellekens; V P Eijsvoogel
Journal:  J Immunol       Date:  1977-09       Impact factor: 5.422

10.  Reconstitution of B and T lymphocyte function in severe combined immunodeficiency disease after transplantation with thymic epithelium.

Authors:  R Hong; M Santosham; H Schulte-Wissermann; S Horowitz; S H Hsu; J A Winkelstein
Journal:  Lancet       Date:  1976-12-11       Impact factor: 79.321
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  6 in total

1.  Multicenter survey on the outcome of transplantation of hematopoietic cells in patients with the complete form of DiGeorge anomaly.

Authors:  Ales Janda; Petr Sedlacek; Manfred Hönig; Wilhelm Friedrich; Martin Champagne; Tadashi Matsumoto; Alain Fischer; Benedicte Neven; Audrey Contet; Danielle Bensoussan; Pierre Bordigoni; David Loeb; William Savage; Nada Jabado; Francisco A Bonilla; Mary A Slatter; E Graham Davies; Andrew R Gennery
Journal:  Blood       Date:  2010-06-07       Impact factor: 22.113

2.  Cultured human thymus epithelial monolayer cells induce CD4 expression on mononuclear cells of AIDS patients in vitro.

Authors:  H J Schuurman; R W Hendriks; J M Lange; J A van der Linden; F H Gmelig Meyling; S A Danner; L Kater
Journal:  Clin Exp Immunol       Date:  1986-05       Impact factor: 4.330

Review 3.  The association between immunodeficiency and congenital heart disease.

Authors:  D J Radford; Y H Thong
Journal:  Pediatr Cardiol       Date:  1988       Impact factor: 1.655

4.  Normalization of the peripheral blood T cell receptor V beta repertoire after cultured postnatal human thymic transplantation in DiGeorge syndrome.

Authors:  C M Davis; T M McLaughlin; T J Watson; R H Buckley; S E Schiff; L P Hale; B F Haynes; M L Markert
Journal:  J Clin Immunol       Date:  1997-03       Impact factor: 8.317

5.  Immunological abnormalities in the syndrome of poliomyelitis-like illness associated with acute bronchial asthma (Hopkin's syndrome).

Authors:  J I Manson; Y H Thong
Journal:  Arch Dis Child       Date:  1980-01       Impact factor: 3.791

Review 6.  The DiGeorge anomaly.

Authors:  R Hong
Journal:  Clin Rev Allergy Immunol       Date:  2001-02       Impact factor: 10.817
  6 in total

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