Literature DB >> 6867632

Evidence for distinct verbal memory pathologies in severely and mildly disturbed schizophrenics.

A Calev, P H Venables, A F Monk.   

Abstract

It is well known that schizophrenics have difficulty in effectively encoding verbal materials into their long-term memories and consequently show a deficit in recall. Recently, orienting tasks were introduced as a method for achieving equivalent to normal encoding and mnemonic organization in schizophrenics; consequently, their deficit in recall disappeared. A detailed review of the literature, however, showed that such effective orienting tasks had only been applied to mildly disturbed schizophrenics (nonchronic, in a good condition). This report presents three experiments which show that more severely disturbed (chronic, hospitalized) schizophrenics, unlike mildly disturbed patients, have memory deficits that cannot be located at the encoding stage. Severely disturbed schizophrenics show (1) a recall deficit, even after effective encoding and mnemonic organization are induced; (2) excessive forgetting over 24- and 48-hour periods; and (3) a recognition memory deficit. These deficits are in addition to their encoding deficit. The use of a matched-tasks check in experiments 2 and 3 suggests that this postencoding deficit is a differential deficit and does not is a differential deficit and does not simply reflect the schizophrenic generalized deficit. Theoretical implications, also supported by the use of various organizational indices (e.g., clustering, hierarchical clustering schemes, and hierarchical grouping analysis), are discussed.

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Year:  1983        PMID: 6867632     DOI: 10.1093/schbul/9.2.247

Source DB:  PubMed          Journal:  Schizophr Bull        ISSN: 0586-7614            Impact factor:   9.306


  12 in total

Review 1.  Scent of a disorder: olfactory functioning in schizophrenia.

Authors:  Paul J Moberg; Bruce I Turetsky
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2.  The metabotropic glutamate 2/3 receptor agonist LY379268 counteracted ketamine-and apomorphine-induced performance deficits in the object recognition task, but not object location task, in rats.

Authors:  Nikolaos Pitsikas; Athina Markou
Journal:  Neuropharmacology       Date:  2014-05-20       Impact factor: 5.250

3.  Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: a longitudinal study.

Authors:  D M Censits; J D Ragland; R C Gur; R E Gur
Journal:  Schizophr Res       Date:  1997-04-11       Impact factor: 4.939

4.  The nitric oxide donor sodium nitroprusside attenuates recognition memory deficits and social withdrawal produced by the NMDA receptor antagonist ketamine and induces anxiolytic-like behaviour in rats.

Authors:  Aikaterini Trevlopoulou; Ntilara Touzlatzi; Nikolaos Pitsikas
Journal:  Psychopharmacology (Berl)       Date:  2015-12-19       Impact factor: 4.530

Review 5.  Cognitive habilitation in schizophrenia: a theoretical review and model of treatment.

Authors:  S Flesher
Journal:  Neuropsychol Rev       Date:  1990-09       Impact factor: 7.444

6.  Assessing declarative memory in schizophrenia using Wisconsin Card Sorting Test stimuli: the Paired Associate Recognition Test.

Authors:  J D Ragland; D M Censits; R C Gur; D C Glahn; F Gallacher; R E Gur
Journal:  Psychiatry Res       Date:  1996-03-29       Impact factor: 3.222

7.  Crocins, the active constituents of Crocus Sativus L., counteracted ketamine-induced behavioural deficits in rats.

Authors:  Georgia Georgiadou; Vasilios Grivas; Petros A Tarantilis; Nikolaos Pitsikas
Journal:  Psychopharmacology (Berl)       Date:  2013-10-06       Impact factor: 4.530

Review 8.  Verbal declarative memory dysfunction in schizophrenia: from clinical assessment to genetics and brain mechanisms.

Authors:  Michael A Cirillo; Larry J Seidman
Journal:  Neuropsychol Rev       Date:  2003-06       Impact factor: 7.444

9.  Cognition and functional outcome among deaf and hearing people with schizophrenia.

Authors:  Heather K Horton; Steven M Silverstein
Journal:  Schizophr Res       Date:  2007-06-07       Impact factor: 4.939

10.  Reduced Hippocampal Volume and Its Relationship With Verbal Memory and Negative Symptoms in Treatment-Naive First-Episode Adolescent-Onset Schizophrenia.

Authors:  Xujun Duan; Changchun He; Jianjun Ou; Runshi Wang; Jinming Xiao; Lei Li; Renrong Wu; Yan Zhang; Jingping Zhao; Huafu Chen
Journal:  Schizophr Bull       Date:  2021-01-23       Impact factor: 9.306

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