Vesicoureteral reflux in the adult. II. Nephropathy, hypertension and stones.

The level of renal function, presence of hypertension or characteristics of nephrolithiasis were analyzed in relation to the severity of renal scarring and other clinical parameters in 67 patients with primary bilateral vesicoureteral reflux. A significant positive correlation was observed between impairment of renal function and severity of renal scarring. Renal insufficiency occurred only in patients with bilateral scarring. Significant proteinuria was found more often in patients with depressed renal function. Hypertension was observed in 34 per cent of the patients, mostly in those with bilateral scarring or depressed renal function. Radiopaque calculi were noted in 18 per cent of the patients. In all but 1 case these calculi occurred in scarred kidneys.