Literature DB >> 6862029

Phosphoenolpyruvate shuttle--transport of energy from mitochondria to cytosol.

Z Drahota, H Rauchová, M Miková, P Kaul, A Bass.   

Abstract

Brown-adipose tissue mitochondria of hamster and rat contain phosphoenolpyruvate carboxykinase (EC 4.1.1.32). In the presence of ketoglutarate and malate, phosphoenolpyruvate is formed and exported from mitochondria. Phosphoenolpyruvate formation is inhibited by 1,2,3-benzenetricarboxylate. It is proposed that phosphoenolpyruvate carboxykinase together with pyruvate carboxylase and pyruvate kinase forms a phosphoenolpyruvate shuttle through which energy produced by the Krebs cycle in mitochondria may be exported to cytosol.

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Year:  1983        PMID： 6862029     DOI： 10.1016/0014-5793(83)80573-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

Review 1.  The mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) and glucose homeostasis: has it been overlooked?

Authors:  Romana Stark; Richard G Kibbey
Journal:  Biochim Biophys Acta       Date:  2013-10-28

2.  Mitochondrial phosphoenolpyruvate carboxykinase deficiency.

Authors:  P T Clayton; K Hyland; M Brand; J V Leonard
Journal:  Eur J Pediatr       Date:  1986-04       Impact factor: 3.183

3.  Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos.

Authors:  Sean R Jesinkey; Anila K Madiraju; Tiago C Alves; OrLando H Yarborough; Rebecca L Cardone; Xiaojian Zhao; Yassmin Parsaei; Ali R Nasiri; Gina Butrico; Xinran Liu; Anthony J Molina; Austin M Rountree; Adam S Neal; Dane M Wolf; John Sterpka; William M Philbrick; Ian R Sweet; Orian H Shirihai; Richard G Kibbey
Journal:  Cell Rep       Date:  2019-07-16       Impact factor: 9.423

Review 4.  Mitochondrial Transport in Glycolysis and Gluconeogenesis: Achievements and Perspectives.

Authors:  Salvatore Passarella; Avital Schurr; Piero Portincasa
Journal:  Int J Mol Sci       Date:  2021-11-23       Impact factor: 5.923

Review 5.  Emerging Roles of Small GTPases in Islet β-Cell Function.

Authors:  Rajakrishnan Veluthakal; Debbie C Thurmond
Journal:  Cells       Date:  2021-06-15       Impact factor: 7.666

6.  Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse Brain.

Authors:  Ernst-Bernhard Kayser; Margaret M Sedensky; Philip G Morgan
Journal:  PLoS One       Date:  2016-01-29       Impact factor: 3.240
  6 in total

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