Literature DB >> 6861976

A technique for the comparison of biological distribution and solvent partition of drugs.

P L Gigon, H van Hees, M H Bickel.   

Abstract

A dialysis technique is described which allows the measurement of drug distribution between buffer and solvents as well as between buffer and biological preparations under identical experimental conditions. Partition and distribution coefficients of thiopental, pentobarbital, imipramine, and chlorpromazine were determined using octanol, other solvents, and tissue homogenates.

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Year:  1983        PMID： 6861976     DOI： 10.1007/bf01990336

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  16 in total

1.  Chemistry of tofranil.

Authors:  F HAEFLIGER
Journal:  Can Psychiatr Assoc J       Date:  1959

2.  The fate of pentobarbital in man and dog and a method for its estimation in biological material.

Authors:  B B BRODIE; J J BURNS; L C MARK; P A LIEF; E BERNSTEIN; E M PAPPER
Journal:  J Pharmacol Exp Ther       Date:  1953-09       Impact factor: 4.030

3.  The dependence of the lipid bilayer membrane: buffer partition coefficient of pentobarbitone on pH and lipid composition.

Authors:  K W Miller; S C Yu
Journal:  Br J Pharmacol       Date:  1977-09       Impact factor: 8.739

4.  Interactions of chlorpromazine and imipramine with artificial membranes investigated by equilibrium dialysis, dual-wavelength photometry, and fluorimetry.

Authors:  J Römer; M H Bickel
Journal:  Biochem Pharmacol       Date:  1979-03-15       Impact factor: 5.858

5.  Ionization constants and water solubilities of some aminoalkylphenothiazine tranquillizers and related compounds.

Authors:  A L Green
Journal:  J Pharm Pharmacol       Date:  1967-01       Impact factor: 3.765

6.  The relationship between the lipophilic nature of tricyclic neuroleptics and antidepressants, and histamine release.

Authors:  M Frisk-Holmberg; E van der Kleijn
Journal:  Eur J Pharmacol       Date:  1972-05       Impact factor: 4.432

7.  The binding of drugs to different polar lipids in vitro.

Authors:  H Lüllmann; M Wehling
Journal:  Biochem Pharmacol       Date:  1979-12-01       Impact factor: 5.858

8.  Decreased viscosity of human erythrocyte suspension induced by chlorpromazine and isoxsuprine.

Authors:  T Suda; D Shimizu; N Maeda; T Shiga
Journal:  Biochem Pharmacol       Date:  1981-08-01       Impact factor: 5.858

9.  Chlorphentermine binding in rat lung subcellular fractions and its displacement by desmethylimipramine.

Authors:  R F Minchin; K F Ilett; B W Madsen
Journal:  Biochem Pharmacol       Date:  1979-08-01       Impact factor: 5.858

10.  Membrane lipids as intracellular binders of chlorpromazine and related drugs.

Authors:  C D Francesco; M H Bickel
Journal:  Chem Biol Interact       Date:  1977-03       Impact factor: 5.192
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