Literature DB >> 6861971

Formation of the active antifertility metabolite of (S)-alpha-chlorohydrin in boar sperm.

A R Jones, D Stevenson.   

Abstract

The male antifertility agent (S)-alpha-chlorohydrin (I) is metabolized by boar sperm to (S)-3-chlorolactaldehyde (II) by an enzyme that is involved in the oxidation of glycerol to glyceraldehyde. The presence of glycerol decreases the activity of this enzyme towards (S)-alpha-chlorohydrin in vitro thereby preventing the formation of (S)-3-chlorolactaldehyde, an inhibitor of glyceraldehyde 3-phosphate dehydrogenase in boar sperm.

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Year:  1983        PMID： 6861971     DOI： 10.1007/bf01990326

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Identification of the biochemical lesion produced by alpha-chlorohydrin in spermatozoa.

Authors:  H Mohri; D A Suter; P D Brown-Woodman; I G White; D D Ridley
Journal:  Nature       Date:  1975-05-01       Impact factor: 49.962

2.  The metabolism of 3-chloro,- 3-bromo- and 3-iodoprpan-1,2-diol in rats and mice.

Authors:  A R Jones
Journal:  Xenobiotica       Date:  1975-03       Impact factor: 1.908

3.  Characterization and antifertility activity in rats of S(+)alpha-chlorohydrin.

Authors:  H Jackson; F R Rooney; R W Fitzpatrick; K H Gibson
Journal:  Chem Biol Interact       Date:  1977-04       Impact factor: 5.192

Review 4.  The antifertility actions of alpha-chlorohydrin in the male.

Authors:  A R Jones
Journal:  Life Sci       Date:  1978-10-23       Impact factor: 5.037

5.  Purification and properties of an NADP + -dependent glycerol dehydrogenase from rabbit skeletal muscle.

Authors:  A W Kormann; R O Hurst; T G Flynn
Journal:  Biochim Biophys Acta       Date:  1972-01-20

Review 6.  Aldehyde reductases: monomeric NADPH-dependent oxidoreductases with multifunctional potential.

Authors:  T G Flynn
Journal:  Biochem Pharmacol       Date:  1982-09-01       Impact factor: 5.858

7.  Inhibition of glycolysis in boar sperm by alpha-chlorohydrin.

Authors:  P Hutton; A G Dawson; A R Jones
Journal:  Contraception       Date:  1980-11       Impact factor: 3.375

8.  Mode of action of alpha-chlorohydrin as a male anti-fertility agent. Inhibition of the metabolism of ram spermatozoa by alpha-chlorohydrin and location of block in glycolysis.

Authors:  P D Brown-Woodman; H Mohri; T Mohri; D Suter; I G White
Journal:  Biochem J       Date:  1978-01-15       Impact factor: 3.857

9.  Inhibition of fructolysis in boar spermatozoa by the male antifertility agent (S)-alpha-chlorohydrin.

Authors:  D Stevenson; A R Jones
Journal:  Aust J Biol Sci       Date:  1982

10.  The effect of the isomers of alpha-cholorohydrin and racemic beta-chlorolactate on the rat kidney.

Authors:  K E Porter; A R Jones
Journal:  Chem Biol Interact       Date:  1982-07-15       Impact factor: 5.192
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  1 in total

1.  Structure of insoluble rat sperm glyceraldehyde-3-phosphate dehydrogenase (GAPDH) via heterotetramer formation with Escherichia coli GAPDH reveals target for contraceptive design.

Authors:  Jan Frayne; Abby Taylor; Gus Cameron; Andrea T Hadfield
Journal:  J Biol Chem       Date:  2009-06-19       Impact factor: 5.157
  1 in total

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