Literature DB >> 6861968

Effect of specific and nonspecific immune complexes on injury of intact hepatocytes in vitro.

H Kawanishi.   

Abstract

Immune complex (IC)-mediated cytotoxicity of hepatocytes was investigated in vitro, using antibodies against specific and nonspecific target cell surface membranes. The results indicated that neither specific, nor nonspecific IC evoked significant lysis of intact hepatocytes. Thus, the IC are unlikely to play an important role in the immune-associated injury of normal hepatocytes in acute and chronic liver diseases.

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Year:  1983        PMID： 6861968     DOI： 10.1007/bf01990318

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

Review 1.  THE LIVER AS AN IMMUNOLOGICAL ORGAN.

Authors:  D R Triger
Journal:  Gastroenterology       Date:  1976-07       Impact factor: 22.682

Review 2.  Immunologic liver injury: the role of hepatitis B viral antigens and liver membrane antigens as targets.

Authors:  K H Meyer zum Büschenfelde; T H Hütteroth; W Arnold; U Hopf
Journal:  Prog Liver Dis       Date:  1979

3.  Chronic liver injury induced by immunologic reactions. Cirrhosis following immunization with heterologous sera.

Authors:  F Paronetto; H Popper
Journal:  Am J Pathol       Date:  1966-12       Impact factor: 4.307

4.  Biliary transport of IgA: role of secretory component.

Authors:  M M Fisher; B Nagy; H Bazin; B J Underdown
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

5.  Liver cell surface localization of hepatitis B antigen and of immunoglobulins in acute and chronic hepatitis and in liver cirrhosis.

Authors:  A Alberti; G Realdi; F Tremolada; G P Spina
Journal:  Clin Exp Immunol       Date:  1976-09       Impact factor: 4.330

6.  Adult liver parenchymal cells in primary culture characteristics and cell recognition standards.

Authors:  R J Bonney
Journal:  In Vitro       Date:  1974 Jul-Aug

7.  HBsAg immune complexes in the course of infection with hepatitis B virus.

Authors:  K Madaliński; I Bragiel
Journal:  Clin Exp Immunol       Date:  1979-06       Impact factor: 4.330

8.  Detection of circulating immune complexes in alcoholic liver disease.

Authors:  E Penner; B Albini; F Milgrom
Journal:  Clin Exp Immunol       Date:  1978-10       Impact factor: 4.330

9.  Prognostic significance of in-vitro complement fixation in liver biopsy specimens from patients with acute viral hepatitis type B.

Authors:  M Rizzetto; F Bonino; S Diana; G Verme
Journal:  Lancet       Date:  1976-08-28       Impact factor: 79.321

10.  Lymphocyte cytotoxicity to autologous liver cells in chronic active hepatitis.

Authors:  K R Wands; K J Isselbacher
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205
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