Literature DB >> 6861884

Calcium-independent release of [3H]dopamine by veratridine in pargyline- and reserpine-treated corpus striatum.

N Y Liang, C O Rutledge.   

Abstract

Veratridine produced a dose-dependent release of cytoplasmic [3H]dopamine in rat corpus striatal slices. Cytoplasmic [3H]dopamine was obtained by pretreating rats with reserpine to inhibit vesicular storage and incubating with pargyline and beta-thujaplicin to inhibit catabolism prior to incubation with [3H]dopamine. Release of [3H]dopamine by veratridine is absolutely calcium-independent and can be abolished by 10(-4) M tetrodotoxin and inhibited by 10(-5) M nomifensine. These results suggest that veratridine can release cytoplasmic [3H]dopamine by a carrier-mediated process.

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Year:  1983        PMID： 6861884     DOI： 10.1016/0014-2999(83)90621-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  3 in total

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Authors:  S M Evans; K J Collard
Journal:  Br J Pharmacol       Date:  1988-11       Impact factor: 8.739

2.  Characterization of the carrier-mediated [3H]GABA release from isolated synaptic plasma membrane vesicles.

Authors:  P P Gonçalves; A P Carvalho
Journal:  Neurochem Res       Date:  1995-02       Impact factor: 3.996

3.  Currents in response to rapid concentration jumps of amphetamine uncover novel aspects of human dopamine transporter function.

Authors:  Kevin Erreger; Christof Grewer; Jonathan A Javitch; Aurelio Galli
Journal:  J Neurosci       Date:  2008-01-23       Impact factor: 6.167
  3 in total

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