Literature DB >> 6861878

Suppression of exploratory locomotor activity in the rat by the local application of 3-PPP enantiomers into the nucleus accumbens.

L Svensson, S Ahlenius.   

Abstract

It was found that (-)-3-PPP, 5-160 microgram/side produced a statistically significant suppression of exploratory locomotor activity after application to the nucleus accumbens. The (+)-isomer was about 8 times less potent in suppressing exploratory activity. Except for suppression of the locomotor activity by 160 micrograms of (-)-3-PPP no statistically significant effects were produced by either isomer applied in the neostriatum.

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Year:  1983        PMID： 6861878     DOI： 10.1016/0014-2999(83)90592-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  12 in total

1.  Mesolimbic dopamine and its control of locomotor activity in rats: differences in pharmacology and light/dark periodicity between the olfactory tubercle and the nucleus accumbens.

Authors:  A R Cools
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

2.  Changes in the amounts of neurotransmitters released from the striatum and spontaneous motor activity in rats exposed to high doses of toluene.

Authors:  H Aikawa; T Yoshida; S Shigeta
Journal:  Environ Health Prev Med       Date:  1997-01       Impact factor: 3.674

Review 3.  Dopamine-receptor agonists: mechanisms underlying autoreceptor selectivity. I. Review of the evidence.

Authors:  D Clark; S Hjorth; A Carlsson
Journal:  J Neural Transm       Date:  1985       Impact factor: 3.575

4.  Antagonism by haloperidol of the suppression of exploratory locomotor activity induced by the local application of (-)3-(3-hydroxyphenyl)-N-n-propylpiperidine into the nucleus accumbens of the rat.

Authors:  S Ahlenius; L Svensson; V Hillegaart; O Thorberg
Journal:  Experientia       Date:  1984-08-15

5.  Differential effects of 3-PPP enantiomers on extracellular dopamine concentration in the caudate-putamen and nucleus accumbens of rats.

Authors:  R E See
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-12       Impact factor: 3.000

6.  Effects of the local application of 3-PPP and sulpiride enantiomers into the nucleus accumbens or into the ventral tegmental area on rat locomotor activity: evidence for the functional importance of somatodendritic autoreceptors.

Authors:  S Ahlenius
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-05       Impact factor: 3.000

7.  Pharmacologic properties of (-)-3PPP (preclamol) in man.

Authors:  C A Tamminga; N G Cascella; R A Lahti; M Lindberg; A Carlsson
Journal:  J Neural Transm Gen Sect       Date:  1992

8.  Effects on locomotor activity after local application of D3 preferring compounds in discrete areas of the rat brain.

Authors:  T Kling-Petersen; E Ljung; K Svensson
Journal:  J Neural Transm Gen Sect       Date:  1995

9.  Effects of (-)3-PPP on acquisition and retention of a conditioned avoidance response in the rat.

Authors:  S Ahlenius; T Archer; B Tandberg; V Hillegaart
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

10.  Modifications of sleep parameters in the rat by (+)- and (-)-3-PPP.

Authors:  S Kafi-de St Hilaire; J Y Sovilla; S Hjorth; J M Gaillard
Journal:  J Neural Transm       Date:  1985       Impact factor: 3.575
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