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Literature DB >> 6860314

Non-metabolizable amino acids are potent stimulators of hepatic and renal ornithine decarboxylase activity.

Abstract

The non-metabolizable amino acids alpha-aminoisobutyric acid (AIB) and cycloleucine and the poorly metabolizable amino acid D-alanine potently stimulated hepatic ornithine decarboxylase (ODC) activity in starved rats. The stimulation by AIB was shown to have several of the characteristics of stimulation by a protein meal and occurred in hypophysectomized animals. AIB also stimulated renal, but not brain or heart, ODC activity.

Entities: Chemical Gene Species

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Year: 1983 PMID： 6860314 PMCID： PMC1154264 DOI： 10.1042/bj2100617

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

16 in total

1. Quantitative nutritional studies with water-soluble, chemically defined diets. III. Individual amino acids as sources of non-essential nitrogen.

Authors: S M BIRNBAUM; M WINITZ; J P GREENSTEIN
Journal: Arch Biochem Biophys Date: 1957-12 Impact factor: 4.013

2. Metabolism in the rat of three amino acids lacking alpha-hydrogen.

Authors: H N CHRISTENSEN; A J ASPEN; E G RICE
Journal: J Biol Chem Date: 1956-05 Impact factor: 5.157

3. Studies on ornithine decarboxylase activity in the isolated perfused rat liver.

Authors: L S Jefferson; A E Pegg
Journal: Biochim Biophys Acta Date: 1977-09-15

4. Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply.

Authors: B L Hogan; S Murden
Journal: J Cell Physiol Date: 1974-06 Impact factor: 6.384

5. Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors.

Authors: D Russell; S H Snyder
Journal: Proc Natl Acad Sci U S A Date: 1968-08 Impact factor: 11.205

Non-metabolizable amino acids are potent stimulators of hepatic and renal ornithine decarboxylase activity.

1. Quantitative nutritional studies with water-soluble, chemically defined diets. III. Individual amino acids as sources of non-essential nitrogen.

2. Metabolism in the rat of three amino acids lacking alpha-hydrogen.

3. Studies on ornithine decarboxylase activity in the isolated perfused rat liver.

4. Effect of growth conditions on the activity of ornithine decarboxylase in cultured hepatoma cells. I. Effect of amino acid supply.

5. Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors.

6. Effects of non-metabolizable analogs on the distribution of amino acids in the rat.

7. Amine synthesis in regenerating rat liver: extremely rapid turnover of ornithine decarboxylase.

8. Hormonal stimulation of hepatic ornithine decarboxylase.

9. Net reabsorption of alpha-aminoisobutyric acid by rat kidney in vivo.

10. Effect of diabetes on the induction of ornithine decarboxylase by refeeding.

1. Induction of ornithine decarboxylase activity by insulin and growth factors is mediated by amino acids.