Literature DB >> 6860146

A new pathway of acrolein metabolism in rats.

W Draminski, E Eder, D Henschler.   

Abstract

The excretion of metabolites of acrolein in rat urine after single oral administration of 10 mg/kg was investigated. S-Carboxyethylmercapturic acid (S-carboxyethyl-N-acetyl-cysteine), or S-(propionic acid methyl ester)mercapturic acid, was found as the major metabolite. An unidentified metabolite was found in expired air. Acrylic acid and methyl acrylate are suggested as intermediates in the metabolism of acrolein.

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Year:  1983        PMID： 6860146     DOI： 10.1007/bf00333903

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  7 in total

Review 1.  Acrolein.

Authors:  C Izard; C Libermann
Journal:  Mutat Res       Date:  1978       Impact factor: 2.433

2.  The metabolic formation of mercapturic acids from allyl halides.

Authors:  C M Kaye; J J Clapp; L Young
Journal:  Xenobiotica       Date:  1972-03       Impact factor: 1.908

3.  Biosynthesis of mercapturic acids from allyl alcohol, allyl esters and acrolein.

Authors:  C M Kaye
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857

4.  Isolation and identification of mercapturic acids of cinnamic aldehyde and cinnamyl alcohol from urine of female rats.

Authors:  L P Delbressine; P J Klippert; J T Reuvers; F Seuttler-Berlage
Journal:  Arch Toxicol       Date:  1981-11       Impact factor: 5.153

5.  Decrease of reduced glutathione in isolated rat hepatocytes caused by acrolein, acrylonitrile, and the thermal degradation products of styrene copolymers.

Authors:  A Zitting; T Heinonen
Journal:  Toxicology       Date:  1980       Impact factor: 4.221

6.  The biotransformation of allyl alcohol and acrolein in rat liver and lung preparations.

Authors:  J M Patel; J C Wood; K C Leibman
Journal:  Drug Metab Dispos       Date:  1980 Sep-Oct       Impact factor: 3.922

7.  Identification or urinary mercapturic acids formed from acrylate, methacrylate and crotonate in the rat.

Authors:  L P Delbressine; F Seutter-Berlage; E Seutter
Journal:  Xenobiotica       Date:  1981-04       Impact factor: 1.908
  7 in total
  4 in total

1.  The role of biotransformation in the genotoxicity of allylic compounds.

Authors:  E Eder; K Dornbusch; G Fischer
Journal:  Arch Toxicol       Date:  1987       Impact factor: 5.153

2.  In vivo absorption, metabolism, and urinary excretion of alpha,beta-unsaturated aldehydes in experimental animals. Relevance to the development of cardiovascular diseases by the dietary ingestion of thermally stressed polyunsaturate-rich culinary oils.

Authors:  M Grootveld; M D Atherton; A N Sheerin; J Hawkes; D R Blake; T E Richens; C J Silwood; E Lynch; A W Claxson
Journal:  J Clin Invest       Date:  1998-03-15       Impact factor: 14.808

3.  Uptake of tobacco smoke constituents on exposure to environmental tobacco smoke (ETS).

Authors:  G Scherer; C Conze; A R Tricker; F Adlkofer
Journal:  Clin Investig       Date:  1992 Mar-Apr

4.  Molecular mechanisms of DNA damage initiated by alpha, beta-unsaturated carbonyl compounds as criteria for genotoxicity and mutagenicity.

Authors:  E Eder; C Hoffman; H Bastian; C Deininger; S Scheckenbach
Journal:  Environ Health Perspect       Date:  1990-08       Impact factor: 9.031
  4 in total

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