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Literature DB >> 6859966

Uric acid effects on in vitro models of rheumatoid inflammatory and autoimmune processes.

R A Turner, E J Pisko, C A Agudelo, G B Counts, S L Foster, W J Treadway.

Abstract

A neutrophil monolayer system was used to study the effects of uric acid on neutrophil-aggregate interactions important in rheumatoid inflammation. No effect on immunoglobulin G aggregate phagocytosis was seen, but hyperuricaemic levels of uric acid were associated with an enhancement of phagocytosis-induced release of the azurophilic granular enzyme beta-glucuronidase. A trinitrophenyl-coupled mononuclear leucocyte rheumatoid factor plaque-forming assay was utilised to study uric acid effects on polyclonal activation of immunocompetent cells. Low levels of uric acid enhanced and high levels suppressed this system. Hyperuricaemia may enhance some aspects of rheumatoid inflammation, while uric acid may modulate an important component of rheumatoid autoimmunity.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1983 PMID： 6859966 PMCID： PMC1001143 DOI： 10.1136/ard.42.3.338

Source DB: PubMed Journal: Ann Rheum Dis ISSN： 0003-4967 Impact factor: 19.103

16 in total

1. The phlogistic potential of urate in solution: studies of the phagocytic process in human leukocytes.

Authors: S E Malawista; G Van Blaricom; S B Cretella; M L Schwartz
Journal: Arthritis Rheum Date: 1979-07

2. Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes.

Authors: G M Shearer
Journal: Eur J Immunol Date: 1974-08 Impact factor: 5.532

3. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

Authors: A Böyum
Journal: Scand J Clin Lab Invest Suppl Date: 1968

1. Studies on the interaction of rheumatoid factor with monosodium urate crystals and case report of coexistent tophaceous gout and rheumatoid arthritis.

Authors: T P Gordon; M J Ahern; C Reid; P J Roberts-Thomson
Journal: Ann Rheum Dis Date: 1985-06 Impact factor: 19.103

1 in total

Uric acid effects on in vitro models of rheumatoid inflammatory and autoimmune processes.

1. The phlogistic potential of urate in solution: studies of the phagocytic process in human leukocytes.

2. Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes.

3. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

4. Use of chromium chloride as the coupling agent in a modified plaque assay. Cells producing anti-protein antibody.

5. Urate deposition disease. How is it regulated and how can it be modified?

6. Generation of human plaque-forming cells in culture: tissue distribution, antigenic and cellular requirements.

7. Drug and rheumatoid factor effects on the uptake of immunoglobulin G aggregates by neurtrophil monolayers.

8. In vitro induction and measurement of hemolytic plaque forming cells in man.

9. Human immune responses to hapten-conjugated cells. I. Primary and secondary proliferative responses in vitro.

10. Neutrophil enzyme activities in rheumatoid inflammation.

1. Studies on the interaction of rheumatoid factor with monosodium urate crystals and case report of coexistent tophaceous gout and rheumatoid arthritis.