Literature DB >> 6857270

Sulfation preceding deiodination of iodothyronines in rat hepatocytes.

M H Otten, J A Mol, T J Visser.   

Abstract

In man and animals iodothyronines are metabolized by deiodination and conjugation with glucuronic acid or sulfate. Until now these processes have been regarded as independent reactions. However, in the present study a close interaction of these pathways was observed in the hepatic metabolism of 3,3'-diiodothyronine and 3,3',5-triiodothyronine. Studies with rat hepatocytes and liver microsomes indicated that sulfation of the phenolic hydroxyl group facilitates the deiodination of these compounds.

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Year:  1983        PMID： 6857270     DOI： 10.1126/science.6857270

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  6 in total

1.  Characterization of bovine tracheobronchial phenol sulphotransferase cDNA and detection of mRNA regulation by cortisol.

Authors:  S J Schauss; T Henry; R Palmatier; L Halvorson; R Dannenbring; J D Beckmann
Journal:  Biochem J       Date:  1995-10-01       Impact factor: 3.857

2.  Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats.

Authors:  H F Escobar-Morreale; M J Obregón; F Escobar del Rey; G Morreale de Escobar
Journal:  J Clin Invest       Date:  1995-12       Impact factor: 14.808

3.  Accumulation of plasma triiodothyronine sulfate in rats treated with propylthiouracil.

Authors:  M Rutgers; F Bonthuis; W W de Herder; T J Visser
Journal:  J Clin Invest       Date:  1987-09       Impact factor: 14.808

4.  Metabolism of reverse triiodothyronine by isolated rat hepatocytes.

Authors:  S J Rooda; M A van Loon; T J Visser
Journal:  J Clin Invest       Date:  1987-06       Impact factor: 14.808

Review 5.  Tissue thyroid hormones and thyronamines.

Authors:  Alice Accorroni; Federica Saponaro; Riccardo Zucchi
Journal:  Heart Fail Rev       Date:  2016-07       Impact factor: 4.214

6.  Treatment of Hypothyroid Patients With L-Thyroxine (L-T4) Plus Triiodothyronine Sulfate (T3S). A Phase II, Open-Label, Single Center, Parallel Groups Study on Therapeutic Efficacy and Tolerability.

Authors:  Ferruccio Santini; Giovanni Ceccarini; Caterina Pelosini; Monica Giannetti; Ilaria Ricco; Giorgia Querci; Enzo Grossi; Giorgio Saponati; Paolo Vitti
Journal:  Front Endocrinol (Lausanne)       Date:  2019-11-29       Impact factor: 5.555
  6 in total

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