Literature DB >> 6857264

Redox delivery system for brain-specific, sustained release of dopamine.

N Bodor, J W Simpkins.   

Abstract

Dopamine was transformed into a redox chemical system for delivery to the brain. The lipoidal form allowed penetration of the blood-brain barrier. Oxidative and hydrolytic processes then transformed the delivery form into a quaternary ammonium precursor of dopamine. The quaternary ammonium precursor was rapidly eliminated from the general circulation, whereas that formed in the brain was locked in, thereby providing a significant and sustained brain-specific dopaminergic activity.

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Year:  1983        PMID： 6857264     DOI： 10.1126/science.6857264

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  A redox-based system that enhances delivery of estradiol to the brain: pharmacokinetic evaluation in the dog.

Authors:  K Dietzel; V Keuth; K S Estes; M E Brewster; R M Clemmons; R Vistelle; N S Bodor; H Derendorf
Journal:  Pharm Res       Date:  1990-08       Impact factor: 4.200

2.  A ¹¹C-labeled 1,4-dihydroquinoline derivative as a potential PET tracer for imaging of redox status in mouse brain.

Authors:  Toshimitsu Okamura; Maki Okada; Tatsuya Kikuchi; Hidekatsu Wakizaka; Ming-Rong Zhang
Journal:  J Cereb Blood Flow Metab       Date:  2015-06-17       Impact factor: 6.200

3.  A redox-based chemical delivery system that enhances estradiol distribution to the brain: disposition studies in the rat.

Authors:  K S Estes; V Keuth; K Dietzel; M E Brewster; N S Bodor; H Derendorf
Journal:  Pharm Res       Date:  1991-09       Impact factor: 4.200

4.  High-performance liquid chromatographic assay of a central nervous system (CNS)-directed estradiol chemical delivery system and its application after intravenous administration to rats.

Authors:  G Mullersman; H Derendorf; M E Brewster; K S Estes; N Bodor
Journal:  Pharm Res       Date:  1988-03       Impact factor: 4.200

5.  Anxiolytic activity of a brain delivery system for GABA.

Authors:  W R Anderson; J W Simpkins; P A Woodard; D Winwood; W C Stern; N Bodor
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

6.  Catecholamine-containing biodegradable microsphere implants as a novel approach in the treatment of CNS neurodegenerative disease. A review of experimental studies in DA-lesioned rats.

Authors:  A McRae; E A Ling; S Hjorth; A Dahlström; D Mason; T Tice
Journal:  Mol Neurobiol       Date:  1994 Aug-Dec       Impact factor: 5.590

7.  The Neurotoxin l-Methyl-4-Phenyl-l,2,3,6-Tetrahydropyridine (MPTP): A Key to Parkinson's Disease?

Authors:  I Irwin
Journal:  Pharm Res       Date:  1986-02       Impact factor: 4.200

Review 8.  Prodrugs for amines.

Authors:  Ana L Simplício; John M Clancy; John F Gilmer
Journal:  Molecules       Date:  2008-03-03       Impact factor: 4.411
  8 in total

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