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Literature DB >> 6857259

Accumulation of D-aspartic acid with age in the human brain.

E H Man, M E Sandhouse, J Burg, G H Fisher.

Abstract

An age-related accumulation of D-aspartic acid was detected in the white matter of ten normal brains from individuals aged 30 to 80 years. Gray matter showed no systematic increase in D-aspartic acid. The rate constant for D-aspartate formation in the brain is equal to the predicted value calculated for 37 degrees C. Accumulation of the uncommon D-aspartate isomer in myelinated white matter implies that there is little or no turnover of this tissue, and this may have a bearing on dysfunction of the aging brain or on other diseases of myelin.

Entities: Chemical Disease Species

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Year: 1983 PMID： 6857259 DOI： 10.1126/science.6857259

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

22 in total

1. Differences in the D/L aspartic acid ratios in dentin among different types of teeth from the same individual and estimated age.

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2. Racemization in enamel among different types of teeth from the same individual.

Authors: Susumu Ohtani; Rei Ito; Szilvia Arany; Toshiharu Yamamoto
Journal: Int J Legal Med Date: 2005-01-12 Impact factor: 2.686

Review 3. Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc.

Authors: Sarit Sara Sivan; Anthony J Hayes; Ellen Wachtel; Bruce Caterson; Yulia Merkher; Alice Maroudas; Sharon Brown; Sally Roberts
Journal: Eur Spine J Date: 2013-04-17 Impact factor: 3.134

4. Collagen fragments in urine derived from bone resorption are highly racemized and isomerized: a biological clock of protein aging with clinical potential.

Authors: P A Cloos; C Fledelius
Journal: Biochem J Date: 2000-02-01 Impact factor: 3.857

Accumulation of D-aspartic acid with age in the human brain.

1. Differences in the D/L aspartic acid ratios in dentin among different types of teeth from the same individual and estimated age.

2. Racemization in enamel among different types of teeth from the same individual.

Review 3. Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc.

4. Collagen fragments in urine derived from bone resorption are highly racemized and isomerized: a biological clock of protein aging with clinical potential.

5. Estimation of chronologic age using the aspartic acid racemization method. I. On human rib cartilage.

6. First evidence on induced topological changes in supercoiled DNA by an aluminium D-aspartate complex.

7. Racemization of aspartic acid in the extracellular matrix proteins of primary and secondary dentin.

8. Factors controlling the level and determination of D-amino acids in the urine and plasma of laboratory rodents.

9. Production and characterization of N-acyl-D-glutamate amidohydrolase from Pseudomonas sp. strain 5f-1.

10. Altered aspartate in Alzheimer neurofibrillary tangles.