Literature DB >> 6856875

Secretogogue responses of leukotriene C4, D4: comparison of potency in canine trachea in vivo.

H G Johnson, M L McNee.   

Abstract

By the use of close arterial injection of leukotrienes into the circulation supplying the upper cervical canine trachea, it has been possible to assess the secretogogue effects of leukotriene C4, and D4 on mucus secretion. Both LTC4 and LTD4 increased mucus secretion over baseline levels by a statistically significant level (p = less than 0.05). LTD4 was more potent than C4 with relative potencies of 2500, 320, 630, and 500 based on hillock formation (a measure of secretion) at 1, 2, 3, and 4 minutes after injection. The overall difference in potency in this animal model of mucus production was LTD4 greater than C4 by 1000-fold.

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Year:  1983        PMID： 6856875     DOI： 10.1016/0090-6980(83)90107-7

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  8 in total

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5.  Adenosine A1 receptor antagonist versus montelukast on airway reactivity and inflammation.

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7.  The importance of leukotrienes in airway inflammation in a mouse model of asthma.

Authors:  W R Henderson; D B Lewis; R K Albert; Y Zhang; W J Lamm; G K Chiang; F Jones; P Eriksen; Y T Tien; M Jonas; E Y Chi
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8.  Studies on the release of leukotrienes and histamine by human lung parenchymal and bronchial fragments upon immunologic and nonimmunologic stimulation. Effects of nordihydroguaiaretic acid, aspirin, and sodium cromoglycate.

Authors:  H Salari; P Borgeat; M Fournier; J Hebert; G Pelletier
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  8 in total

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